A preliminary observation of weight loss following left gastric artery embolization in humans

Andrew J. Gunn, Rahmi Oklu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background/Objectives. Embolization of the left gastric artery (LGA), which preferentially supplies the gastric fundus, has been shown to produce weight loss in animal models. However, weight loss after LGA embolization in humans has not been previously established. The aim of this study was to evaluate postprocedural weight loss in patients following LGA embolization. Subjects/Methods. A retrospective analysis of the medical records of patients who underwent LGA embolization for upper gastrointestinal (GI) bleeding was performed. Postprocedural weight loss in this group was compared to a control group of patients who had undergone embolization of other arteries for upper GI bleeding. Results. The experimental group (N=19) lost an average of 7.3% of their initial body weight within three months of LGA embolization, which was significantly greater than the 2% weight loss observed in the control group (N=28) (P=0.006). No significant differences were seen between the groups in preprocedural body mass index (BMI), age, postprocedural care in the intensive care unit, history of malignancy, serum creatinine, or left ventricular ejection fraction. Conclusions. The current data suggest that body weight in humans may be modulated via LGA embolization. Continued research is warranted with prospective studies to further investigate this phenomenon.

Original languageEnglish (US)
Article number185349
JournalJournal of Obesity
Volume2014
DOIs
StatePublished - 2014
Externally publishedYes

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Weight Loss
Stomach
Arteries
Observation
Body Weight
Gastric Fundus
Hemorrhage
Control Groups
Stroke Volume
Medical Records
Intensive Care Units
Creatinine
Body Mass Index
Animal Models
Prospective Studies
Serum
Research
Neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

A preliminary observation of weight loss following left gastric artery embolization in humans. / Gunn, Andrew J.; Oklu, Rahmi.

In: Journal of Obesity, Vol. 2014, 185349, 2014.

Research output: Contribution to journalArticle

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abstract = "Background/Objectives. Embolization of the left gastric artery (LGA), which preferentially supplies the gastric fundus, has been shown to produce weight loss in animal models. However, weight loss after LGA embolization in humans has not been previously established. The aim of this study was to evaluate postprocedural weight loss in patients following LGA embolization. Subjects/Methods. A retrospective analysis of the medical records of patients who underwent LGA embolization for upper gastrointestinal (GI) bleeding was performed. Postprocedural weight loss in this group was compared to a control group of patients who had undergone embolization of other arteries for upper GI bleeding. Results. The experimental group (N=19) lost an average of 7.3{\%} of their initial body weight within three months of LGA embolization, which was significantly greater than the 2{\%} weight loss observed in the control group (N=28) (P=0.006). No significant differences were seen between the groups in preprocedural body mass index (BMI), age, postprocedural care in the intensive care unit, history of malignancy, serum creatinine, or left ventricular ejection fraction. Conclusions. The current data suggest that body weight in humans may be modulated via LGA embolization. Continued research is warranted with prospective studies to further investigate this phenomenon.",
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