TY - JOUR
T1 - A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior
AU - Caselli, Richard J.
AU - Chen, Kewei
AU - Bandy, Dan
AU - Smilovici, Oded
AU - Boeve, Bradley F.
AU - Osborne, David
AU - Alexander, Gene E.
AU - Parish, James M.
AU - Krahn, Lois E.
AU - Reiman, Eric M.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67% women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85%), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.
AB - Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67% women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85%), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.
KW - Dementia with Lewy bodies
KW - Preclinical dementia
KW - REM sleep behavior disorder
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U2 - 10.1093/sleep/29.7.927
DO - 10.1093/sleep/29.7.927
M3 - Article
C2 - 16895260
AN - SCOPUS:33745714307
SN - 0161-8105
VL - 29
SP - 927
EP - 933
JO - Sleep
JF - Sleep
IS - 7
ER -