A predictive diagnostic model using multiparametric MRI for differentiating uterine carcinosarcoma from carcinoma of the uterine corpus

Yuki Kamishima, Mitsuru Takeuchi, Tatsuya Kawai, Takatsune Kawaguchi, Ken Yamaguchi, Naoki Takahashi, Masato Ito, Toshinao Arakawa, Akiko Yamamoto, Kazushi Suzuki, Masaki Ogawa, Moe Takeuchi, Yuta Shibamoto

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To construct a diagnostic model for differentiating carcinosarcoma from carcinoma of the uterus. Materials and methods: Twenty-six patients with carcinosarcomas and 26 with uterine corpus carcinomas constituted a derivation cohort. The following nine MRI features of the tumors were evaluated: inhomogeneity, predominant signal intensity, presence of hyper- and hypointense areas, conspicuity of tumor margin, cervical canal extension on T2WI, presence of hyperintense areas on T1WI, contrast defect area volume percentage, and degree of enhancement. Two predictive models—with and without contrast—were constructed using multivariate logistic regression analysis. Fifteen other patients with carcinosarcomas and 30 patients with carcinomas constituted a validation cohort. The sensitivity and specificity of each model for the validation cohort were calculated. Results: Inhomogeneity, predominant signal intensity on T2WI, and presence of hyperintense areas on T1WI were significant predictors in the unenhanced-MRI-based model. Presence of hyperintensity on T1WI, contrast defect area volume percentage, and degree of enhancement were significant predictors in the enhanced-MRI-based model. The sensitivity/specificity of unenhanced MRI were 87/73 and 87/70% according to reviewer 1 and 2, respectively. The sensitivity/specificity of the enhanced-MRI-based model were 87/70% according to both reviewers. Conclusions: Our diagnostic models can differentiate carcinosarcoma from carcinoma of the uterus with high sensitivity and moderate specificity.

Original languageEnglish (US)
Pages (from-to)472-483
Number of pages12
JournalJapanese Journal of Radiology
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • Carcinoma
  • Carcinosarcoma
  • Endometrial neoplasms
  • Magnetic resonance imaging
  • Uterus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kamishima, Y., Takeuchi, M., Kawai, T., Kawaguchi, T., Yamaguchi, K., Takahashi, N., Ito, M., Arakawa, T., Yamamoto, A., Suzuki, K., Ogawa, M., Takeuchi, M., & Shibamoto, Y. (2017). A predictive diagnostic model using multiparametric MRI for differentiating uterine carcinosarcoma from carcinoma of the uterine corpus. Japanese Journal of Radiology, 35(8), 472-483. https://doi.org/10.1007/s11604-017-0655-6