A practical review of the emerging direct anticoagulants, laboratory monitoring, and reversal agents

Stephanie A. Joppa; Justin Salciccioli; Jill Adamski; Salma Patel; Waldemar Wysokinski; Robert McBane; Farah Al-Saffar; Heidi Esser; Fadi Shamoun

doi:10.3390/jcm7020029

A practical review of the emerging direct anticoagulants, laboratory monitoring, and reversal agents

Stephanie A. Joppa, Justin Salciccioli, Jill Adamski, Salma Patel, Waldemar Wysokinski, Robert McBane, Farah Al-Saffar, Heidi Esser, Fadi Shamoun

Research output: Contribution to journal › Review article › peer-review

Abstract

Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.

Original language	English (US)
Article number	29
Journal	Journal of Clinical Medicine
Volume	7
Issue number	2
DOIs	https://doi.org/10.3390/jcm7020029
State	Published - Feb 11 2018

Keywords

Anticoagulants
Reversal agents
Serum levels

ASJC Scopus subject areas

Medicine(all)

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10.3390/jcm7020029

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title = "A practical review of the emerging direct anticoagulants, laboratory monitoring, and reversal agents",

abstract = "Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.",

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AU - Joppa, Stephanie A.

AU - Salciccioli, Justin

AU - Adamski, Jill

AU - Patel, Salma

AU - Wysokinski, Waldemar

AU - McBane, Robert

AU - Al-Saffar, Farah

AU - Esser, Heidi

AU - Shamoun, Fadi

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AB - Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.

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KW - Reversal agents

KW - Serum levels

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A practical review of the emerging direct anticoagulants, laboratory monitoring, and reversal agents

Abstract

Keywords

ASJC Scopus subject areas

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