A practical guide for treatment of rapidly progressive ADPKD with tolvaptan

Fouad T. Chebib, Ronald D. Perrone, Arlene B. Chapman, Neera K. Dahl, Peter C. Harris, Michal Mrug, Reem A. Mustafa, Anjay Rastogi, Terry Watnick, Alan S.L. Yu, Vicente E. Torres

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

In the past, the treatment of autosomal dominant polycystic kidney disease (ADPKD) has been limited to the management of its symptoms and complications. Recently, the US Food and Drug Administration (FDA) approved tolvaptan as the first drug treatment to slow kidney function decline in adults at risk of rapidly progressing ADPKD. Full prescribing information approved by the FDA provides helpful guidelines but does not address practical questions that are being raised by nephrologists, internists, and general practitioners taking care of patients with ADPKD, and by the patients themselves. In this review, we provide practical guidance and discuss steps that require consideration before and after prescribing tolvaptan to patients with ADPKD to ensure that this treatment is implemented safely and effectively. These steps include confirmation of diagnosis; identification of rapidly progressive disease; implementation of basic renal protective measures; counseling of patients on potential benefits and harms; exclusions to use; education of patients on aquaresis and its expected consequences; initiation, titration, and optimization of tolvaptan treatment; prevention of aquaresis-related complications; evaluation and management of liver enzyme elevations; and monitoring of treatment efficacy. Our recommendations are made on the basis of published evidence and our collective experiences during the randomized, clinical trials and open-label extension studies of tolvaptan in ADPKD.

Original languageEnglish (US)
Pages (from-to)2458-2470
Number of pages13
JournalJournal of the American Society of Nephrology
Volume29
Issue number10
DOIs
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Nephrology

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    Chebib, F. T., Perrone, R. D., Chapman, A. B., Dahl, N. K., Harris, P. C., Mrug, M., Mustafa, R. A., Rastogi, A., Watnick, T., Yu, A. S. L., & Torres, V. E. (2018). A practical guide for treatment of rapidly progressive ADPKD with tolvaptan. Journal of the American Society of Nephrology, 29(10), 2458-2470. https://doi.org/10.1681/ASN.2018060590