TY - JOUR
T1 - A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia
AU - Colon-Otero, G.
AU - Menke, D.
AU - Hook, C. C.
PY - 1992
Y1 - 1992
N2 - The most common causes of macrocytic anemias in the adults are (1) alcoholism, (2) liver diseases, (3) hemolysis or bleeding, (4) hypothyroidism, (5) folate or vitamin B12 deficiency, (6) exposure to chemotherapy and other drugs, and (7) myelodysplasia. A carefully obtained history and examination with evaluation of a peripheral blood smear and reticulocyte count should be performed in most patients with macrocytosis. Serum vitamin B12 and folate levels, serum thyroid studies, liver function studies, and bone marrow aspirate and biopsy with cytogenetic analysis are frequently required to confirm a diagnosis suspected on the basis of the initial evaluation.
AB - The most common causes of macrocytic anemias in the adults are (1) alcoholism, (2) liver diseases, (3) hemolysis or bleeding, (4) hypothyroidism, (5) folate or vitamin B12 deficiency, (6) exposure to chemotherapy and other drugs, and (7) myelodysplasia. A carefully obtained history and examination with evaluation of a peripheral blood smear and reticulocyte count should be performed in most patients with macrocytosis. Serum vitamin B12 and folate levels, serum thyroid studies, liver function studies, and bone marrow aspirate and biopsy with cytogenetic analysis are frequently required to confirm a diagnosis suspected on the basis of the initial evaluation.
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U2 - 10.1016/S0025-7125(16)30341-8
DO - 10.1016/S0025-7125(16)30341-8
M3 - Article
C2 - 1578958
AN - SCOPUS:0026651205
SN - 0025-7125
VL - 76
SP - 581
EP - 597
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 3
ER -