A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia

G. Colon-Otero, D. Menke, C. C. Hook

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

The most common causes of macrocytic anemias in the adults are (1) alcoholism, (2) liver diseases, (3) hemolysis or bleeding, (4) hypothyroidism, (5) folate or vitamin B12 deficiency, (6) exposure to chemotherapy and other drugs, and (7) myelodysplasia. A carefully obtained history and examination with evaluation of a peripheral blood smear and reticulocyte count should be performed in most patients with macrocytosis. Serum vitamin B12 and folate levels, serum thyroid studies, liver function studies, and bone marrow aspirate and biopsy with cytogenetic analysis are frequently required to confirm a diagnosis suspected on the basis of the initial evaluation.

Original languageEnglish (US)
Pages (from-to)581-597
Number of pages17
JournalMedical Clinics of North America
Volume76
Issue number3
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Medicine(all)

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