A potential role for CD8+ T-cells as regulators of CNS vascular permeability

Georgette L. Suidan, Istvan Pirko, Aaron J. Johnson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The role of immune cells in promoting central nervous system (CNS) vascular permeability is poorly understood. In recent years, there is a growing body of literature that suggests CD8+ T-cells are potent mediators of vascular permeability in peripheral viral infections as well as in immune mediated neurological diseases. This review outlines the recent advances in tissue culture and animal models used to study vascular permeability. In addition, we put forth our hypothesis that CD8+ T-cells promote the opening of tight junctions between cerebral endothelial cells, enabling the infiltration of white blood cells and in certain models even leading to microhemorrhages in the CNS. Determining the mechanism by which CD8+ T-cells and other immune cells promote CNS vascular permeability in animal models could define new targets for immune mediated neurological conditions characterized by vascular permeability.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalNeurological Research
Volume28
Issue number3
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Capillary Permeability
Central Nervous System
T-Lymphocytes
Animal Models
Tight Junctions
Virus Diseases
Leukocytes
Endothelial Cells

Keywords

  • Blood-brain barrier (BBB)
  • CD8 T cell
  • Relapsing remitting multiple sclerosis
  • Tight junction
  • Vascular permeability
  • Viral hemorrhagic fever

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

A potential role for CD8+ T-cells as regulators of CNS vascular permeability. / Suidan, Georgette L.; Pirko, Istvan; Johnson, Aaron J.

In: Neurological Research, Vol. 28, No. 3, 04.2006, p. 250-255.

Research output: Contribution to journalArticle

Suidan, Georgette L. ; Pirko, Istvan ; Johnson, Aaron J. / A potential role for CD8+ T-cells as regulators of CNS vascular permeability. In: Neurological Research. 2006 ; Vol. 28, No. 3. pp. 250-255.
@article{6735367c733a4202a8e0018f50021996,
title = "A potential role for CD8+ T-cells as regulators of CNS vascular permeability",
abstract = "The role of immune cells in promoting central nervous system (CNS) vascular permeability is poorly understood. In recent years, there is a growing body of literature that suggests CD8+ T-cells are potent mediators of vascular permeability in peripheral viral infections as well as in immune mediated neurological diseases. This review outlines the recent advances in tissue culture and animal models used to study vascular permeability. In addition, we put forth our hypothesis that CD8+ T-cells promote the opening of tight junctions between cerebral endothelial cells, enabling the infiltration of white blood cells and in certain models even leading to microhemorrhages in the CNS. Determining the mechanism by which CD8+ T-cells and other immune cells promote CNS vascular permeability in animal models could define new targets for immune mediated neurological conditions characterized by vascular permeability.",
keywords = "Blood-brain barrier (BBB), CD8 T cell, Relapsing remitting multiple sclerosis, Tight junction, Vascular permeability, Viral hemorrhagic fever",
author = "Suidan, {Georgette L.} and Istvan Pirko and Johnson, {Aaron J.}",
year = "2006",
month = "4",
doi = "10.1179/016164106X98116",
language = "English (US)",
volume = "28",
pages = "250--255",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "3",

}

TY - JOUR

T1 - A potential role for CD8+ T-cells as regulators of CNS vascular permeability

AU - Suidan, Georgette L.

AU - Pirko, Istvan

AU - Johnson, Aaron J.

PY - 2006/4

Y1 - 2006/4

N2 - The role of immune cells in promoting central nervous system (CNS) vascular permeability is poorly understood. In recent years, there is a growing body of literature that suggests CD8+ T-cells are potent mediators of vascular permeability in peripheral viral infections as well as in immune mediated neurological diseases. This review outlines the recent advances in tissue culture and animal models used to study vascular permeability. In addition, we put forth our hypothesis that CD8+ T-cells promote the opening of tight junctions between cerebral endothelial cells, enabling the infiltration of white blood cells and in certain models even leading to microhemorrhages in the CNS. Determining the mechanism by which CD8+ T-cells and other immune cells promote CNS vascular permeability in animal models could define new targets for immune mediated neurological conditions characterized by vascular permeability.

AB - The role of immune cells in promoting central nervous system (CNS) vascular permeability is poorly understood. In recent years, there is a growing body of literature that suggests CD8+ T-cells are potent mediators of vascular permeability in peripheral viral infections as well as in immune mediated neurological diseases. This review outlines the recent advances in tissue culture and animal models used to study vascular permeability. In addition, we put forth our hypothesis that CD8+ T-cells promote the opening of tight junctions between cerebral endothelial cells, enabling the infiltration of white blood cells and in certain models even leading to microhemorrhages in the CNS. Determining the mechanism by which CD8+ T-cells and other immune cells promote CNS vascular permeability in animal models could define new targets for immune mediated neurological conditions characterized by vascular permeability.

KW - Blood-brain barrier (BBB)

KW - CD8 T cell

KW - Relapsing remitting multiple sclerosis

KW - Tight junction

KW - Vascular permeability

KW - Viral hemorrhagic fever

UR - http://www.scopus.com/inward/record.url?scp=33646787408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646787408&partnerID=8YFLogxK

U2 - 10.1179/016164106X98116

DO - 10.1179/016164106X98116

M3 - Article

C2 - 16687049

AN - SCOPUS:33646787408

VL - 28

SP - 250

EP - 255

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 3

ER -