A possible role for systemic hypoxia in the reactive component of pulmonary hypertension in heart failure

Bryan J. Taylor, Cesar R. Mojica, Thomas P. Olson, Paul R. Woods, Robert P. Frantz, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: The mechanisms underlying the reactive component of pulmonary hypertension (PH) in heart failure (HF) are unclear. We examined whether resting systemic oxygen levels are related to pulmonary hemodynamics in HF. Methods and Results: Thirty-nine HF patients underwent right heart catheterization. Subsequently, patients were classified as having: 1) no PH (n = 12); 2) passive PH (n = 10); or 3) reactive PH (n = 17). Blood was drawn from the radial and pulmonary arteries for the determination of PaO2, SaO2, PvO2, SvO2, and vasoactive neurohormones. PaO2 and PvO2 were lower in reactive PH versus no PH and passive PH patients (65.3 ± 8.6 vs 78.3 ± 11.4 mm Hg and 74.5 ± 14.0 mm Hg; 29.2 ± 4.1 vs 36.2 ± 2.8 mm Hg and 33.4 ± 2.3 mm Hg; P < .05). SaO2 and SvO2 were lower in reactive PH versus no PH patients (93 ± 3% vs 96 ± 3%; 51 ± 11% vs 68 ± 4%; P < .05), but not different versus passive PH patients. The transpulmonary pressure gradient (TPG) was inversely related to PaO2, PvO2, SaO2, and SvO2 in the reactive PH patients only (r ≤ -0.557; P < .05). Similarly, plasma endothelin-1 correlated with PaO2, PvO2, SvO2 (r ≤ -0.495), and TPG (r = 0.662; P < .05) in reactive PH patients only. Conclusions: Systemic hypoxia may play a role in the reactive component of PH in HF, potentially via a hypoxia-induced increase in endothelial release of the vasoconstrictor endothelin-1.

Original languageEnglish (US)
Pages (from-to)50-59
Number of pages10
JournalJournal of Cardiac Failure
Volume19
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Transpulmonary pressure gradient
  • arterial and venous oxygen pressure and saturation
  • endothelin-1
  • neurohormones

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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