A population perspective on diagnostic criteria for Parkinson's disease

Maarten C. De Rijk, Walter A Rocca, D. W. Anderson, M. O. Melcon, M. M B Breteler, D. M. Maraganore

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

For Parkinson's disease (PD), little is known about how the choice of diagnostic criteria affects research results. Using data on PD from three community studies (from Argentina, the Netherlands, Italy), we compared the impact on prevalence of several sets of diagnostic criteria. Each set was based on cardinal signs-resting tremor, bradykinesia, rigidity, impaired postural reflexes-and required that other parkinsonism be excluded. Some sets had additional requirements related to duration of symptoms, asymmetry of signs, or response to medication. In terms of prevalence, much lower estimates were associated with the requirements of asymmetry of signs and response to medication. The assessment of these clinical features may not be practical in community studies. Impaired postural reflexes, as a cardinal sign, seemed superfluous. For community studies of PD, we recommend the following diagnostic criteria: at least two of resting tremor, bradykinesia, or rigidity, in the absence of other apparent causes of parkinsonism.

Original languageEnglish (US)
Pages (from-to)1277-1281
Number of pages5
JournalNeurology
Volume48
Issue number5
StatePublished - May 1997

Fingerprint

Parkinson Disease
Hypokinesia
Parkinsonian Disorders
Tremor
Reflex
Population
Argentina
Netherlands
Italy
Signs and Symptoms
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

De Rijk, M. C., Rocca, W. A., Anderson, D. W., Melcon, M. O., Breteler, M. M. B., & Maraganore, D. M. (1997). A population perspective on diagnostic criteria for Parkinson's disease. Neurology, 48(5), 1277-1281.

A population perspective on diagnostic criteria for Parkinson's disease. / De Rijk, Maarten C.; Rocca, Walter A; Anderson, D. W.; Melcon, M. O.; Breteler, M. M B; Maraganore, D. M.

In: Neurology, Vol. 48, No. 5, 05.1997, p. 1277-1281.

Research output: Contribution to journalArticle

De Rijk, MC, Rocca, WA, Anderson, DW, Melcon, MO, Breteler, MMB & Maraganore, DM 1997, 'A population perspective on diagnostic criteria for Parkinson's disease', Neurology, vol. 48, no. 5, pp. 1277-1281.
De Rijk MC, Rocca WA, Anderson DW, Melcon MO, Breteler MMB, Maraganore DM. A population perspective on diagnostic criteria for Parkinson's disease. Neurology. 1997 May;48(5):1277-1281.
De Rijk, Maarten C. ; Rocca, Walter A ; Anderson, D. W. ; Melcon, M. O. ; Breteler, M. M B ; Maraganore, D. M. / A population perspective on diagnostic criteria for Parkinson's disease. In: Neurology. 1997 ; Vol. 48, No. 5. pp. 1277-1281.
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