A population-based study of vaginal human papillomavirus infection in hysterectomized women

Philip E. Castle, Mark Schiffman, M. Concepcion Bratti, Allan Hildesheim, Rolando Herrero, Martha L. Hutchinson, Ana Cecilia Rodriguez, Sholom Wacholder, Mark E. Sherman, Hortense Kendall, Raphael P. Viscidi, Jose Jeronimo, John E. Schussler, Robert D. Burk

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60 Scopus citations

Abstract

We compared point prevalences and determinants of human papillomavirus (HPV) DNA detection by testing enrollment vaginal specimens from hysterectomized women (n = 569) and enrollment cervical specimens from nonhysterectomized women (n = 6098) ≥30 years old, using MY09/MY11 L1 consensus-primer polymerase chain reaction. The subjects were participating in a population-based cohort study (n = 10,049) in Guanacaste, Costa Rica, that was initiated in 1993. Non-cancer-associated HPV types, especially types 61, 71, and 72, were detected more frequently in the vaginal specimens from hysterectomized women (23.7% [95% confidence interval {CI}, 20.3%-27.4%]) than in the cervical specimens from nonhysterectomized women (16.7% [95% CI, 15.7%-17.6%]) (P = .0001). There was no difference between the prevalences of cancer-associated HPV types in hysterectomized women and those in nonhysterectomized women; in both groups, the prevalence of HPV DNA was greater in women with multiple lifetime sex partners. We infer from our data that the cervical transformation zone may not be needed for cancer-associated HPV infection but may be uniquely susceptible to HPV-induced carcinogenesis; we also infer that specific phylogenetic groups of HPV (i.e., A3/A4/A15) may have a predilection for vaginal epithelium.

Original languageEnglish (US)
Pages (from-to)458-467
Number of pages10
JournalJournal of Infectious Diseases
Volume190
Issue number3
DOIs
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Castle, P. E., Schiffman, M., Bratti, M. C., Hildesheim, A., Herrero, R., Hutchinson, M. L., Rodriguez, A. C., Wacholder, S., Sherman, M. E., Kendall, H., Viscidi, R. P., Jeronimo, J., Schussler, J. E., & Burk, R. D. (2004). A population-based study of vaginal human papillomavirus infection in hysterectomized women. Journal of Infectious Diseases, 190(3), 458-467. https://doi.org/10.1086/421916