TY - JOUR
T1 - A population-based study of vaginal human papillomavirus infection in hysterectomized women
AU - Castle, Philip E.
AU - Schiffman, Mark
AU - Bratti, M. Concepcion
AU - Hildesheim, Allan
AU - Herrero, Rolando
AU - Hutchinson, Martha L.
AU - Rodriguez, Ana Cecilia
AU - Wacholder, Sholom
AU - Sherman, Mark E.
AU - Kendall, Hortense
AU - Viscidi, Raphael P.
AU - Jeronimo, Jose
AU - Schussler, John E.
AU - Burk, Robert D.
N1 - Funding Information:
Financial support: National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, and the Costa Rican Foundation for Training in Health Sciences (Public Health Service contracts N01CP21081 and N01CP31061); NIH (grant CA78527 to R.D.B.).
PY - 2004/8/1
Y1 - 2004/8/1
N2 - We compared point prevalences and determinants of human papillomavirus (HPV) DNA detection by testing enrollment vaginal specimens from hysterectomized women (n = 569) and enrollment cervical specimens from nonhysterectomized women (n = 6098) ≥30 years old, using MY09/MY11 L1 consensus-primer polymerase chain reaction. The subjects were participating in a population-based cohort study (n = 10,049) in Guanacaste, Costa Rica, that was initiated in 1993. Non-cancer-associated HPV types, especially types 61, 71, and 72, were detected more frequently in the vaginal specimens from hysterectomized women (23.7% [95% confidence interval {CI}, 20.3%-27.4%]) than in the cervical specimens from nonhysterectomized women (16.7% [95% CI, 15.7%-17.6%]) (P = .0001). There was no difference between the prevalences of cancer-associated HPV types in hysterectomized women and those in nonhysterectomized women; in both groups, the prevalence of HPV DNA was greater in women with multiple lifetime sex partners. We infer from our data that the cervical transformation zone may not be needed for cancer-associated HPV infection but may be uniquely susceptible to HPV-induced carcinogenesis; we also infer that specific phylogenetic groups of HPV (i.e., A3/A4/A15) may have a predilection for vaginal epithelium.
AB - We compared point prevalences and determinants of human papillomavirus (HPV) DNA detection by testing enrollment vaginal specimens from hysterectomized women (n = 569) and enrollment cervical specimens from nonhysterectomized women (n = 6098) ≥30 years old, using MY09/MY11 L1 consensus-primer polymerase chain reaction. The subjects were participating in a population-based cohort study (n = 10,049) in Guanacaste, Costa Rica, that was initiated in 1993. Non-cancer-associated HPV types, especially types 61, 71, and 72, were detected more frequently in the vaginal specimens from hysterectomized women (23.7% [95% confidence interval {CI}, 20.3%-27.4%]) than in the cervical specimens from nonhysterectomized women (16.7% [95% CI, 15.7%-17.6%]) (P = .0001). There was no difference between the prevalences of cancer-associated HPV types in hysterectomized women and those in nonhysterectomized women; in both groups, the prevalence of HPV DNA was greater in women with multiple lifetime sex partners. We infer from our data that the cervical transformation zone may not be needed for cancer-associated HPV infection but may be uniquely susceptible to HPV-induced carcinogenesis; we also infer that specific phylogenetic groups of HPV (i.e., A3/A4/A15) may have a predilection for vaginal epithelium.
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U2 - 10.1086/421916
DO - 10.1086/421916
M3 - Article
C2 - 15243917
AN - SCOPUS:3242747495
SN - 0022-1899
VL - 190
SP - 458
EP - 467
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -