A population-based study of sociodemographic and geographic variation in hpv vaccination

Lila J Rutten, Patrick M. Wilson, Debra J. Jacobson, Amenah A. Agunwamba, Carmen Radecki Breitkopf, Robert M. Jacobson, Jennifer St. Sauver

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Human papillomavirus (HPV) vaccination rates in the United States remain low and lag behind other recommended adolescent vaccines. Studies evaluating the association of geographic and area-level characteristics with HPV vaccination rates provide a valuable resource for public health planning. Method: We used the Rochester Epidemiology Project data linkage system to ascertain HPV vaccination rates between 2010 and 2015 in a 7-county region of southern Minnesota. Geocoded individual patient data were spatially linked to socioeconomic data from the American Community Survey at the census block group level. Bayesian hierarchical logistic regression was used to model incident vaccination rates, adjusting for individual-and area-level sociodemographic characteristics, and geolocation. Geolocation was modeled as an approximated Gaussian field using a Stochastic Partial Differential Equations approach. All models were estimated using Integrated Nested Laplace Approximations. Results: In adjusted models, increasing age and female sex were associated with increased HPV vaccination. Lower socioeconomic status was associated with decreased rates of initiation [adjusted odds ratio (AOR); 95% confidence interval 0.90 (0.86-0.95)], completion of the second dose [AOR 0.88 (0.83-0.93)], and completion of the third dose [AOR 0.85 (0.80-0.92)]. Geographic spatial analysis demonstrated increased odds of vaccination for the eastern region and in the greater Rochester metropolitan area, showing significant spatial variation not explained by individual level characteristics and ACS block group-level data. Conclusions: HPV vaccination rates varied geographically and by individual and geographically indexed sociodemographic characteristics. Impact: Identifying geographic regions with low HPV vaccination rates can help target clinical and community efforts to improve vaccination rates.

Original languageEnglish (US)
Pages (from-to)533-540
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2017

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Vaccination
Population
Odds Ratio
Geographic Mapping
Health Planning
Spatial Analysis
Information Storage and Retrieval
Censuses
Information Systems
Social Class
Epidemiology
Vaccines
Public Health
Logistic Models
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

A population-based study of sociodemographic and geographic variation in hpv vaccination. / Rutten, Lila J; Wilson, Patrick M.; Jacobson, Debra J.; Agunwamba, Amenah A.; Radecki Breitkopf, Carmen; Jacobson, Robert M.; St. Sauver, Jennifer.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 26, No. 4, 01.04.2017, p. 533-540.

Research output: Contribution to journalArticle

Rutten, Lila J ; Wilson, Patrick M. ; Jacobson, Debra J. ; Agunwamba, Amenah A. ; Radecki Breitkopf, Carmen ; Jacobson, Robert M. ; St. Sauver, Jennifer. / A population-based study of sociodemographic and geographic variation in hpv vaccination. In: Cancer Epidemiology Biomarkers and Prevention. 2017 ; Vol. 26, No. 4. pp. 533-540.
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