TY - JOUR
T1 - A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy
AU - Nguyen, Trinh T.
AU - Smith, Carin Y.
AU - Gazzuola Rocca, Liliana
AU - Rocca, Walter A.
AU - Vassallo, Robert
AU - Dulohery Scrodin, Megan M.
N1 - Funding Information:
W.A.R. has received research support from the National Institutes of Health (R01 AG052425, RF1 AG055151, U54 AG044170, U01 AG006786, and R33 AG058738). R.V. has received research support from the NIH (HL140486, HL142061, and AI147394) as well as research grant funding from Pfizer, Bristol Myers Squibb, and Sun Pharmaceuticals for research unrelated to this study. For the remaining authors, no conflicts were declared. No author had conflicts of interest directly related to the subject of this manuscript.
Funding Information:
The Mayo Clinic Cohort Study of Oophorectomy and Aging (MOA-2) used the resources of the Rochester Epidemiology Project (REP) medical records-linkage system, which is supported by the National Institute on Aging (NIA; R33 AG058738), by the Mayo Clinic Research Committee, and by fees paid annually by REP users. However, the content of this article is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health (NIH) or the Mayo Clinic. W.A.R. was partly funded by the grants U54 AG044170 and RF1 AG055151 from the National Institute on Aging, National Institutes of Health, and by the Ralph S. and Beverley E. Caulkins Professorship of Neurodegenerative Diseases Research of the Mayo Clinic.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - There is increasing evidence that sex hormones may impact the development of obstructive lung disease (OLD). Therefore, we studied the effect of bilateral oophorectomy (oophorectomy) on the development of OLD. Women were identified from the Mayo Clinic Cohort Study of Oophorectomy and Aging-2. Data were collected using the Rochester Epidemiology Project records-linkage system. A total of 1653 women who underwent oophorectomy and 1653 referent women of similar age were assessed for OLD using diagnostic codes and medical record abstraction. Women who underwent oophorectomy had an overall higher risk of all OLD, all chronic obstructive pulmonary disease (COPD), emphysema, and chronic bronchitis but not of all asthma, confirmed asthma, or confirmed COPD. The association with all OLD was stronger in women who were age ≤45 years at oophorectomy, never smokers, non-obese, and in women with benign indications; however, the interactions were not statistically significant. There was an increased risk of all asthma in women age ≤45 years at oophorectomy who took estrogen therapy. Never smokers of all ages had a stronger association of oophorectomy with all asthma and all COPD, whereas smokers had a stronger association of oophorectomy with emphysema and chronic bronchitis. Non-obese women of all ages had a stronger association of oophorectomy with all COPD, emphysema, and chronic bronchitis. The results of this study combined with the increased risk of several chronic diseases reported in previous studies suggest that oophorectomy in premenopausal women should be avoided unless there is clear evidence of a high genetic risk of ovarian cancer.
AB - There is increasing evidence that sex hormones may impact the development of obstructive lung disease (OLD). Therefore, we studied the effect of bilateral oophorectomy (oophorectomy) on the development of OLD. Women were identified from the Mayo Clinic Cohort Study of Oophorectomy and Aging-2. Data were collected using the Rochester Epidemiology Project records-linkage system. A total of 1653 women who underwent oophorectomy and 1653 referent women of similar age were assessed for OLD using diagnostic codes and medical record abstraction. Women who underwent oophorectomy had an overall higher risk of all OLD, all chronic obstructive pulmonary disease (COPD), emphysema, and chronic bronchitis but not of all asthma, confirmed asthma, or confirmed COPD. The association with all OLD was stronger in women who were age ≤45 years at oophorectomy, never smokers, non-obese, and in women with benign indications; however, the interactions were not statistically significant. There was an increased risk of all asthma in women age ≤45 years at oophorectomy who took estrogen therapy. Never smokers of all ages had a stronger association of oophorectomy with all asthma and all COPD, whereas smokers had a stronger association of oophorectomy with emphysema and chronic bronchitis. Non-obese women of all ages had a stronger association of oophorectomy with all COPD, emphysema, and chronic bronchitis. The results of this study combined with the increased risk of several chronic diseases reported in previous studies suggest that oophorectomy in premenopausal women should be avoided unless there is clear evidence of a high genetic risk of ovarian cancer.
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U2 - 10.1038/s41533-022-00317-4
DO - 10.1038/s41533-022-00317-4
M3 - Article
C2 - 36376327
AN - SCOPUS:85141974742
VL - 32
JO - npj Primary Care Respiratory Medicine
JF - npj Primary Care Respiratory Medicine
SN - 2055-1010
IS - 1
M1 - 52
ER -