A population-based case-control study of the tumor necrosis factor alpha -308 polymorphism in multiple sclerosis

Dean Marko Wingerchuk, Q. Liu, J. Sobell, S. Sommer, Brian G Weinshenker

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Tumor necrosis factor alpha (TNFα) expression is enhanced in patients with active MS and other inflammatory diseases. A guanine-to-adenine polymorphism at position -308 of the TNFα promoter region (the TNF2 allele) is associated with increased TNFα expression. We evaluated 110 MS patients derived from an Olmsted County, MN, prevalence study. Three other patient cohorts (autoimmune, serious infectious illness, and other neurologic diseases) and matched controls were derived from a Mayo Clinic DNA bank. We used polymerase chain reaction amplification of specific alleles to screen for the TNF2 allele and to determine zygosity. We found one homozygote and 29 heterozygotes in the MS patients. There was no association between the presence of the TNF2 allele and MS or the other disease categories by matched-pair and group analyses.

Original languageEnglish (US)
Pages (from-to)626-628
Number of pages3
JournalNeurology
Volume49
Issue number2
StatePublished - Aug 1997

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Multiple Sclerosis
Case-Control Studies
Tumor Necrosis Factor-alpha
Alleles
Population
Matched-Pair Analysis
Homozygote
Guanine
Adenine
Heterozygote
Nervous System Diseases
Genetic Promoter Regions
Research Design
Cross-Sectional Studies
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A population-based case-control study of the tumor necrosis factor alpha -308 polymorphism in multiple sclerosis. / Wingerchuk, Dean Marko; Liu, Q.; Sobell, J.; Sommer, S.; Weinshenker, Brian G.

In: Neurology, Vol. 49, No. 2, 08.1997, p. 626-628.

Research output: Contribution to journalArticle

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