A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk

H. Dean Hosgood, Mark P. Purdue, Sophia S. Wang, Tongzhang Zheng, Lindsay M. Morton, Qing Lan, Idan Menashe, Yawei Zhang, James R. Cerhan, Andrew Grulich, Wendy Cozen, Meredith Yeager, Theodore R. Holford, Claire M. Vajdic, Scott Davis, Brian Leaderer, Anne Kricker, Maryjean Schenk, Shelia H. Zahm, Nilanjan ChatterjeeStephen J. Chanock, Nathaniel Rothman, Patricia Hartge, Bruce Armstrong

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Genetic variation in immune-related genes may play a role in the development of non-Hodgkin lymphoma (NHL). To test the hypothesis that innate immunity polymorphisms may be associated with NHL risk, we genotyped 144 tag single nucleotide polymorphisms (tagSNPs) capturing common genetic variation within 12 innate immunity gene regions in three independent population-based case-control studies (1946 cases and 1808 controls). Gene-based analyses found IL1RN to be associated with NHL risk (minP=0·03); specifically, IL1RN rs2637988 was associated with an increased risk of NHL (per-allele odds ratio=1·15, 95% confidence interval=1·05-1·27; Ptrend=0·003), which was consistent across study, subtype, and gender. FCGR2A was also associated with a decreased risk of the follicular lymphoma NHL subtype (minP=0·03). Our findings suggest that genetic variation in IL1RN and FCGR2A may play a role in lymphomagenesis. Given that conflicting results have been reported regarding the association between IL1RN SNPs and NHL risk, a larger number of innate immunity genes with sufficient genomic coverage should be evaluated systematically across many studies. Published 2011. This article is a US Government work and is in the public domain in the USA..

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalBritish journal of haematology
Volume152
Issue number6
DOIs
StatePublished - Mar 2011

Keywords

  • Genetic variation
  • Immune
  • Innate immunity
  • Non-Hodgkin lymphoma
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Hematology

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    Hosgood, H. D., Purdue, M. P., Wang, S. S., Zheng, T., Morton, L. M., Lan, Q., Menashe, I., Zhang, Y., Cerhan, J. R., Grulich, A., Cozen, W., Yeager, M., Holford, T. R., Vajdic, C. M., Davis, S., Leaderer, B., Kricker, A., Schenk, M., Zahm, S. H., ... Armstrong, B. (2011). A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk. British journal of haematology, 152(6), 721-726. https://doi.org/10.1111/j.1365-2141.2010.08518.x