A pooled analysis of posttransplant survival following combined heart-liver transplantation

Neal R. Barshes, Ian W. Udell, David L. Joyce, Robert E. Southard, Christine A. O'Mahony, John A. Goss

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Because no single center has accumulated a large experience with this complex operation, the effectiveness of combined orthotopic heart transplantation (OHT) and orthotopic liver transplantation (OLT) in achieving long-term survival has been unknown. Cases of OHT-OLT were pooled from a U.S. transplant recipient registry and from previously published literature. Aggregate data from these sources was used for survival analysis. Thirty-six patients having undergone OHT-OLT were listed in the national registry; the one- and five-year patient survival rates of these patients were 88% and 78%, respectively. Many patients remain alive at 8+ years after transplantation. An analysis of the pooled results of previously-published cases estimated a one-year patient survival rate of 84%. In selected disease processes, OHT-OLT can correct underlying metabolic deficiencies. While rarely indicated, OHT-OLT is a successful treatment for patients with end-stage heart and liver disease, with survival comparable to that seen after isolated orthotopic heart or orthotopic liver transplantation.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalTransplantation
Volume83
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Heart transplant
  • Liver transplant
  • Metabolic disorder
  • Multiorgan transplant
  • Outcomes

ASJC Scopus subject areas

  • Transplantation

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    Barshes, N. R., Udell, I. W., Joyce, D. L., Southard, R. E., O'Mahony, C. A., & Goss, J. A. (2007). A pooled analysis of posttransplant survival following combined heart-liver transplantation. Transplantation, 83(1), 95-98. https://doi.org/10.1097/01.tp.0000243731.29657.87