Abstract
Background: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. Methods: We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p
| Original language | English (US) |
|---|---|
| Article number | 978 |
| Journal | BMC Cancer |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 16 2015 |
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Keywords
- Anthracyclines
- Chemotherapy
- Genetic variation
- Radiotherapy
- Survival
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Genetics
Cite this
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. / Seibold, Petra; Schmezer, Peter; Behrens, Sabine; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Flesch-Janys, Dieter; Nevanlinna, Heli; Fagerholm, Rainer; Aittomäki, Kristiina; Blomqvist, Carl; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli Matti; Hartikainen, Jaana M.; Lambrechts, Diether; Wildiers, Hans; Kristensen, Vessela; Alnæs, Grethe Grenaker; Nord, Silje; Borresen-Dale, Anne Lise; Hooning, Maartje J.; Hollestelle, Antoinette; Jager, Agnes; Seynaeve, Caroline; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Dunning, Alison M.; Rhenius, Valerie; Shah, Mitul; Kabisch, Maria; Torres, Diana; Ulmer, Hans Ulrich; Hamann, Ute; Schildkraut, Joellen M.; Purrington, Kristen S.; Couch, Fergus J; Hall, Per; Pharoah, Paul; Easton, Doug F.; Schmidt, Marjanka K.; Chang-Claude, Jenny; Popanda, Odilia.
In: BMC Cancer, Vol. 15, No. 1, 978, 16.12.2015.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
AU - Seibold, Petra
AU - Schmezer, Peter
AU - Behrens, Sabine
AU - Michailidou, Kyriaki
AU - Bolla, Manjeet K.
AU - Wang, Qin
AU - Flesch-Janys, Dieter
AU - Nevanlinna, Heli
AU - Fagerholm, Rainer
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Margolin, Sara
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli Matti
AU - Hartikainen, Jaana M.
AU - Lambrechts, Diether
AU - Wildiers, Hans
AU - Kristensen, Vessela
AU - Alnæs, Grethe Grenaker
AU - Nord, Silje
AU - Borresen-Dale, Anne Lise
AU - Hooning, Maartje J.
AU - Hollestelle, Antoinette
AU - Jager, Agnes
AU - Seynaeve, Caroline
AU - Li, Jingmei
AU - Liu, Jianjun
AU - Humphreys, Keith
AU - Dunning, Alison M.
AU - Rhenius, Valerie
AU - Shah, Mitul
AU - Kabisch, Maria
AU - Torres, Diana
AU - Ulmer, Hans Ulrich
AU - Hamann, Ute
AU - Schildkraut, Joellen M.
AU - Purrington, Kristen S.
AU - Couch, Fergus J
AU - Hall, Per
AU - Pharoah, Paul
AU - Easton, Doug F.
AU - Schmidt, Marjanka K.
AU - Chang-Claude, Jenny
AU - Popanda, Odilia
PY - 2015/12/16
Y1 - 2015/12/16
N2 - Background: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. Methods: We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p
AB - Background: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. Methods: We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p
KW - Anthracyclines
KW - Chemotherapy
KW - Genetic variation
KW - Radiotherapy
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84959139071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959139071&partnerID=8YFLogxK
U2 - 10.1186/s12885-015-1957-7
DO - 10.1186/s12885-015-1957-7
M3 - Article
C2 - 26674097
AN - SCOPUS:84959139071
VL - 15
JO - BMC Cancer
JF - BMC Cancer
SN - 1471-2407
IS - 1
M1 - 978
ER -