A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Petra Seibold, Peter Schmezer, Sabine Behrens, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Dieter Flesch-Janys, Heli Nevanlinna, Rainer Fagerholm, Kristiina Aittomäki, Carl Blomqvist, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli Matti Kosma, Jaana M. Hartikainen, Diether Lambrechts, Hans Wildiers, Vessela Kristensen, Grethe Grenaker AlnæsSilje Nord, Anne Lise Borresen-Dale, Maartje J. Hooning, Antoinette Hollestelle, Agnes Jager, Caroline Seynaeve, Jingmei Li, Jianjun Liu, Keith Humphreys, Alison M. Dunning, Valerie Rhenius, Mitul Shah, Maria Kabisch, Diana Torres, Hans Ulrich Ulmer, Ute Hamann, Joellen M. Schildkraut, Kristen S. Purrington, Fergus J Couch, Per Hall, Paul Pharoah, Doug F. Easton, Marjanka K. Schmidt, Jenny Chang-Claude, Odilia Popanda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. Methods: We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p

Original languageEnglish (US)
Article number978
JournalBMC Cancer
Volume15
Issue number1
DOIs
StatePublished - Dec 16 2015

Fingerprint

DNA Repair
Breast Neoplasms
Drug Therapy
DNA Damage
Single Nucleotide Polymorphism
Survival
Radiotherapy
Genes
Anthracyclines
Adjuvant Chemotherapy
Cell Death
Therapeutics
Neoplasms

Keywords

  • Anthracyclines
  • Chemotherapy
  • Genetic variation
  • Radiotherapy
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. / Seibold, Petra; Schmezer, Peter; Behrens, Sabine; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Flesch-Janys, Dieter; Nevanlinna, Heli; Fagerholm, Rainer; Aittomäki, Kristiina; Blomqvist, Carl; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli Matti; Hartikainen, Jaana M.; Lambrechts, Diether; Wildiers, Hans; Kristensen, Vessela; Alnæs, Grethe Grenaker; Nord, Silje; Borresen-Dale, Anne Lise; Hooning, Maartje J.; Hollestelle, Antoinette; Jager, Agnes; Seynaeve, Caroline; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Dunning, Alison M.; Rhenius, Valerie; Shah, Mitul; Kabisch, Maria; Torres, Diana; Ulmer, Hans Ulrich; Hamann, Ute; Schildkraut, Joellen M.; Purrington, Kristen S.; Couch, Fergus J; Hall, Per; Pharoah, Paul; Easton, Doug F.; Schmidt, Marjanka K.; Chang-Claude, Jenny; Popanda, Odilia.

In: BMC Cancer, Vol. 15, No. 1, 978, 16.12.2015.

Research output: Contribution to journalArticle

Seibold, P, Schmezer, P, Behrens, S, Michailidou, K, Bolla, MK, Wang, Q, Flesch-Janys, D, Nevanlinna, H, Fagerholm, R, Aittomäki, K, Blomqvist, C, Margolin, S, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Lambrechts, D, Wildiers, H, Kristensen, V, Alnæs, GG, Nord, S, Borresen-Dale, AL, Hooning, MJ, Hollestelle, A, Jager, A, Seynaeve, C, Li, J, Liu, J, Humphreys, K, Dunning, AM, Rhenius, V, Shah, M, Kabisch, M, Torres, D, Ulmer, HU, Hamann, U, Schildkraut, JM, Purrington, KS, Couch, FJ, Hall, P, Pharoah, P, Easton, DF, Schmidt, MK, Chang-Claude, J & Popanda, O 2015, 'A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients', BMC Cancer, vol. 15, no. 1, 978. https://doi.org/10.1186/s12885-015-1957-7
Seibold, Petra ; Schmezer, Peter ; Behrens, Sabine ; Michailidou, Kyriaki ; Bolla, Manjeet K. ; Wang, Qin ; Flesch-Janys, Dieter ; Nevanlinna, Heli ; Fagerholm, Rainer ; Aittomäki, Kristiina ; Blomqvist, Carl ; Margolin, Sara ; Mannermaa, Arto ; Kataja, Vesa ; Kosma, Veli Matti ; Hartikainen, Jaana M. ; Lambrechts, Diether ; Wildiers, Hans ; Kristensen, Vessela ; Alnæs, Grethe Grenaker ; Nord, Silje ; Borresen-Dale, Anne Lise ; Hooning, Maartje J. ; Hollestelle, Antoinette ; Jager, Agnes ; Seynaeve, Caroline ; Li, Jingmei ; Liu, Jianjun ; Humphreys, Keith ; Dunning, Alison M. ; Rhenius, Valerie ; Shah, Mitul ; Kabisch, Maria ; Torres, Diana ; Ulmer, Hans Ulrich ; Hamann, Ute ; Schildkraut, Joellen M. ; Purrington, Kristen S. ; Couch, Fergus J ; Hall, Per ; Pharoah, Paul ; Easton, Doug F. ; Schmidt, Marjanka K. ; Chang-Claude, Jenny ; Popanda, Odilia. / A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. In: BMC Cancer. 2015 ; Vol. 15, No. 1.
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abstract = "Background: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. Methods: We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p",
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T1 - A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

AU - Seibold, Petra

AU - Schmezer, Peter

AU - Behrens, Sabine

AU - Michailidou, Kyriaki

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Flesch-Janys, Dieter

AU - Nevanlinna, Heli

AU - Fagerholm, Rainer

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli Matti

AU - Hartikainen, Jaana M.

AU - Lambrechts, Diether

AU - Wildiers, Hans

AU - Kristensen, Vessela

AU - Alnæs, Grethe Grenaker

AU - Nord, Silje

AU - Borresen-Dale, Anne Lise

AU - Hooning, Maartje J.

AU - Hollestelle, Antoinette

AU - Jager, Agnes

AU - Seynaeve, Caroline

AU - Li, Jingmei

AU - Liu, Jianjun

AU - Humphreys, Keith

AU - Dunning, Alison M.

AU - Rhenius, Valerie

AU - Shah, Mitul

AU - Kabisch, Maria

AU - Torres, Diana

AU - Ulmer, Hans Ulrich

AU - Hamann, Ute

AU - Schildkraut, Joellen M.

AU - Purrington, Kristen S.

AU - Couch, Fergus J

AU - Hall, Per

AU - Pharoah, Paul

AU - Easton, Doug F.

AU - Schmidt, Marjanka K.

AU - Chang-Claude, Jenny

AU - Popanda, Odilia

PY - 2015/12/16

Y1 - 2015/12/16

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KW - Anthracyclines

KW - Chemotherapy

KW - Genetic variation

KW - Radiotherapy

KW - Survival

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