A placebo-controlled trial of buspirone for the treatment of marijuana dependence

Aimee L. McRae-Clark, Rickey E. Carter, Therese K. Killeen, Matthew J. Carpenter, Amy E. Wahlquist, Stacey A. Simpson, Kathleen T. Brady

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49 Scopus citations

Abstract

The present study investigated the potential efficacy of buspirone for treating marijuana dependence. Participants received either buspirone (maximum 60 mg/day) (n = 23) or matching placebo (n = 27) for 12 weeks, each in conjunction with motivational interviewing. In the modified intention-to-treat analysis, the percentage of negative UDS results in the buspirone-treatment group was 18 percentage points higher than the placebo-treatment group (95% CI: -2% to 37%, p = 0.071). On self-report, participants receiving buspirone reported not using marijuana 45.2% of days and participants receiving placebo reported not using 51.4% of days (p = 0.55). An analysis of participants that completed the 12-week trial showed a significant difference in the percentage negative UDS (95% CI: 7-63%, p = 0.014) and a trend for participants randomized to the buspirone-treatment group who completed treatment to achieve the first negative UDS result sooner than those participants treated with placebo (p = 0.054). Further study with buspirone in this population may be warranted; however, strategies to enhance study retention and improve outcome measurement should be considered in future trials.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalDrug and Alcohol Dependence
Volume105
Issue number1-2
DOIs
StatePublished - Nov 1 2009

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Keywords

  • Buspirone
  • Marijuana
  • Motivational interviewing
  • Placebo

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

McRae-Clark, A. L., Carter, R. E., Killeen, T. K., Carpenter, M. J., Wahlquist, A. E., Simpson, S. A., & Brady, K. T. (2009). A placebo-controlled trial of buspirone for the treatment of marijuana dependence. Drug and Alcohol Dependence, 105(1-2), 132-138. https://doi.org/10.1016/j.drugalcdep.2009.06.022