A pilot study of the effects of sildenafil on stool characteristics, colon transit, anal sphincter function, and rectal sensation in healthy men

Mark Milone, John K. DiBaise

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Nitric oxide is an important mediator of gut smooth muscle relaxation and visceral sensation. Sildenafil results in stimulation of the nitric oxide-cyclic GMP pathway. We sought to determine the effects of daily sildenafil administration on colorectal function. Over a 4-week period, sildenafil was administered during weeks 2 and 3. Stool frequency and consistency were assessed daily. Anorectal manometry, rectal sensation, and colon transit testing were performed at the end of weeks 1 and 3. Ten healthy men were studied. No significant differences in segmental or total colon transit time were noted; however, significant changes in stool frequency and trends toward decreased stool consistency were noted during sildenafil use. A trend toward reduced resting anal sphincter pressure was seen after sildenafil. Rectal volumes to first sensation and desire to defecate were significantly increased after sildenafil on test day 2 only. Additionally, volumes to desire to defecate and maximal tolerable volume were significantly increased before sildenafil on test day 2 compared to before sildenafil on test day 1. We conclude that daily administration of sildenafil is well tolerated and results in alterations in colorectal function.

Original languageEnglish (US)
Pages (from-to)1005-1011
Number of pages7
JournalDigestive diseases and sciences
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2005

Keywords

  • Anal sphincter
  • Colon transit
  • Rectal sensation
  • Sildenafil

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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