A Pilot Study of Splenic and Whole Body Retention of Autologous Radiolabeled Leukocytes in the Assessment of Severity in Inflammatory Colitis

F. Anderson Rowe, Michael Camilleri, Lee A. Forstrom, Kenneth P. Batts, Brian P. Mullan, George M. Thomforde, William Dunn, Alan R. Zinsmeister

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To assess the splenic and whole body retention of radiolaheled autologous leukocytes over 24 or 48 h as measures of the severity of colitis. Eleven patients with colitis underwent standardized clinical, endoscopic, histological, and 111in‐labeled leukocyte scintigraphy. A logistic discriminant analysis was used to estimate weighting factors for morphological indices, serum alhumen, and stool excretion of 111in over 24 h that predicted the clinical assessmenl of severity. Subsequently, Spearman rank correlation analysis estimated associations among reductions in spleen and whole body radioactivity and the derived indices of in flammation. The reduction in spleen counts over 24 h correlates significantly with morphological indices (rs= 0.83, p < 0.005) and with serum albumen and stool 111In (functional index, rs= 0.77, p < 0.01). Similarly, the reduction in whole body 111in over 48 h correlates significantly with the combined index (rs= 0.8) and with the morphological and functional index separately (rs= 0.72 and 0.79, respectively). This pilot study identified weighting factors for morphological and functional indices in assessing severity of colitis; reduction in whole body and splenic retention of radioactivity was sufficient for evaluation of severity of colitis without the need for stool collections.

Original languageEnglish (US)
Pages (from-to)1771-1775
Number of pages5
JournalThe American Journal of Gastroenterology
Volume90
Issue number10
DOIs
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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