A pilot study of high-dose intraarterial cisplatin chemotherapy with concomitant accelerated radiotherapy for patients with previously untreated T4 and selected patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tract

Robert L. Foote, Jan Kasperbauer, Scott Heitaka Okuno, Douglas A. Nichols, Kerry D. Olsen, Paul D. Brown, Yolanda Isabel Garces, Daniel J. Sargent, Scott E. Strome

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Abstract

BACKGROUND. This Phase I clinical trial was developed to assess the feasibility of combining high-dose intraarterial cisplatin chemotherapy with concurrent, concomitant boost accelerated radiation therapy for patients with previously untreated T4 and select patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tract. METHODS. Between July 1999, and February 2002, 19 patients were treated with 3 or 4 weekly cycles of intraarterial Cisplatin chemotherapy (150 mg/m2) with concurrent, concomitant boost accelerated radiation therapy (72 grays in 42 fractions over 6 weeks). RESULTS. Two patient deaths occurred among the first 15 patients enrolled. Both patients presented with febrile neutropenia, and both died of complications related to infection. The number of cycles of intraarterial cisplatin was reduced from four cycles to three cycles, and an additional four patients were treated. The fourth patient treated on the modified protocol developed febrile neutropenia, sepsis, and a thromboembolic event, which resulted in lower extremity amputations. The maximum acute toxicity experienced was Grade 2 in 6 patients, Grade 3 in 5 patients, Grade 4 in 6 patients, and Grade 5 in 2 patients. With a median follow-up of 21 months (range, 6.2-34.6 months), the overall survival at 1 year was 89.5% (95% confidence interval [95%CI], 76.7-100%), At 1 year, 92.9% of the patients were free from disease progression (95%CI, 80.3-100%). CONCLUSIONS. The results of this study suggest that concurrent intraarterial cisplatin chemotherapy at a dose of 150 mg/m 2 with concomitant boost accelerated radiation therapy is not feasible.

Original languageEnglish (US)
Pages (from-to)559-568
Number of pages10
JournalCancer
Volume103
Issue number3
DOIs
StatePublished - Feb 1 2005

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Keywords

  • Accelerated radiation therapy
  • Acute toxicity
  • Head and neck carcinoma
  • Intraarterial chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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A pilot study of high-dose intraarterial cisplatin chemotherapy with concomitant accelerated radiotherapy for patients with previously untreated T4 and selected patients with T3N0-N3M0 squamous cell carcinoma of the upper aerodigestive tract. / Foote, Robert L.; Kasperbauer, Jan; Okuno, Scott Heitaka; Nichols, Douglas A.; Olsen, Kerry D.; Brown, Paul D.; Garces, Yolanda Isabel; Sargent, Daniel J.; Strome, Scott E.

In: Cancer, Vol. 103, No. 3, 01.02.2005, p. 559-568.

Research output: Contribution to journalArticle