A pilot study of GABAB correlates with resting-state functional connectivity in five depressed female adolescents

Irena Balzekas, Charles P. Lewis, Julia Shekunov, John D Port, Gregory Alan Worrell, Hang Joon Jo, Paul E Croarkin

Research output: Contribution to journalArticle

Abstract

Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.

Original languageEnglish (US)
JournalPsychiatry Research - Neuroimaging
DOIs
StateAccepted/In press - Jan 1 2018

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Major Depressive Disorder
Biomarkers
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
Research
Inhibition (Psychology)
Therapeutics

Keywords

  • Connectivity
  • Depression
  • Resting state
  • TMS, fMRI

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

A pilot study of GABAB correlates with resting-state functional connectivity in five depressed female adolescents. / Balzekas, Irena; Lewis, Charles P.; Shekunov, Julia; Port, John D; Worrell, Gregory Alan; Joon Jo, Hang; Croarkin, Paul E.

In: Psychiatry Research - Neuroimaging, 01.01.2018.

Research output: Contribution to journalArticle

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