A pilot study of GABA                         B                          correlates with resting-state functional connectivity in five depressed female adolescents

Irena Balzekas; Charles P. Lewis; Julia Shekunov; John D. Port; Gregory A. Worrell; Hang Joon Jo; Paul E. Croarkin

doi:10.1016/j.pscychresns.2018.05.013

A pilot study of GABA _B correlates with resting-state functional connectivity in five depressed female adolescents

Irena Balzekas, Charles P. Lewis, Julia Shekunov, John D. Port, Gregory A. Worrell, Hang Joon Jo, Paul E. Croarkin

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	279
DOIs	https://doi.org/10.1016/j.pscychresns.2018.05.013
State	Published - Sep 30 2018

Keywords

Connectivity
Depression
Resting state
TMS, fMRI

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Access to Document

10.1016/j.pscychresns.2018.05.013

Cite this

Balzekas, I., Lewis, C. P., Shekunov, J., Port, J. D., Worrell, G. A., Joon Jo, H., & Croarkin, P. E. (2018). A pilot study of GABA _B correlates with resting-state functional connectivity in five depressed female adolescents Psychiatry Research - Neuroimaging, 279, 60-63. https://doi.org/10.1016/j.pscychresns.2018.05.013

A pilot study of GABA _B correlates with resting-state functional connectivity in five depressed female adolescents . / Balzekas, Irena; Lewis, Charles P.; Shekunov, Julia et al.
In: Psychiatry Research - Neuroimaging, Vol. 279, 30.09.2018, p. 60-63.

Research output: Contribution to journal › Article › peer-review

Balzekas, I, Lewis, CP, Shekunov, J, Port, JD , Worrell, GA, Joon Jo, H & Croarkin, PE 2018, ' A pilot study of GABA _B correlates with resting-state functional connectivity in five depressed female adolescents ', Psychiatry Research - Neuroimaging, vol. 279, pp. 60-63. https://doi.org/10.1016/j.pscychresns.2018.05.013

Balzekas I, Lewis CP, Shekunov J, Port JD , Worrell GA, Joon Jo H et al. A pilot study of GABA _B correlates with resting-state functional connectivity in five depressed female adolescents Psychiatry Research - Neuroimaging. 2018 Sep 30;279:60-63. doi: 10.1016/j.pscychresns.2018.05.013

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abstract = "Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.",

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