A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072

Rache M. Simmons, Karla V. Ballman, Charles Cox, Ned Carp, Jennifer Sabol, Rosa F. Hwang, Deanna Attai, Michael Sabel, David Nathanson, Andrew Kenler, Linsey Gold, Cary Kaufman, Linda Han, Aaron Bleznak, J. Stanley Smith, Dennis Holmes, Bruno Fornage, Carisa Le-Petross, Syed Hoda, Linda McCallKelly K. Hunt, Behalf Of The Acosog Investigators On Behalf Of The Acosog Investigators

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25 Scopus citations

Abstract

Background: Cryoablation is a well-established technique to treat fibroadenomas. Pilot studies suggest this could be an effective non-surgical treatment for breast cancer. American College of Surgeons Oncology Group Z1072 is a phase II trial exploring the effectiveness of cryoablation in the treatment of breast cancers. Methods: The primary endpoint of Z1072 was the rate of complete tumor ablation, defined as no remaining invasive breast cancer (IBC) or ductal carcinoma in situ (DCIS) on pathologic examination of the targeted lesion. A secondary objective was to evaluate the negative predictive value of magnetic resonance imaging (MRI) to determine residual IBC or DCIS. Eligible patients included those with unifocal invasive ductal breast cancer ≤2 cm, with

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAnnals of Surgical Oncology
DOIs
StateAccepted/In press - May 24 2016

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ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Simmons, R. M., Ballman, K. V., Cox, C., Carp, N., Sabol, J., Hwang, R. F., Attai, D., Sabel, M., Nathanson, D., Kenler, A., Gold, L., Kaufman, C., Han, L., Bleznak, A., Stanley Smith, J., Holmes, D., Fornage, B., Le-Petross, C., Hoda, S., ... On Behalf Of The Acosog Investigators, B. O. T. A. I. (Accepted/In press). A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072. Annals of Surgical Oncology, 1-8. https://doi.org/10.1245/s10434-016-5275-3