TY - JOUR
T1 - A phase II study of recombinant human alpha‐interferon in advanced hormone‐refractory prostate cancer
AU - Van Haelst‐Pisani, Carol M.
AU - Richardson, Ronald L.
AU - Su, John
AU - Buckner, Jan C.
AU - Hahn, Richard G.
AU - Frytak, Stephen
AU - Kvols, Larry K.
AU - Burch, Patrick A.
PY - 1992/11/1
Y1 - 1992/11/1
N2 - To determine the efficacy of recombinant human leukocyte alpha‐interferon (IFL‐RA) in advanced hormone‐refractory prostate cancer, the authors treated 40 patients with IFL‐RA administered intramuscularly at a dose of 10 × 108 U/m2 three times weekly. Toxicity was substantial and necessitated at least a 50% dose reduction in all but five patients during the first 1‐2 months of therapy. No responses were observed in patients with bone metastases, but complete and partial regression of nodal disease were observed in two patients with extraosseous disease (overall response rate, 5%; 95% confidence interval, 0.64‐17.75%). The authors conclude that IFL‐RA cannot be recommended at this dose and schedule in patients with advanced prostate cancer, but additional study of its use in patients with nodal disease may be warranted. Cancer 1992; 702310‐2312.
AB - To determine the efficacy of recombinant human leukocyte alpha‐interferon (IFL‐RA) in advanced hormone‐refractory prostate cancer, the authors treated 40 patients with IFL‐RA administered intramuscularly at a dose of 10 × 108 U/m2 three times weekly. Toxicity was substantial and necessitated at least a 50% dose reduction in all but five patients during the first 1‐2 months of therapy. No responses were observed in patients with bone metastases, but complete and partial regression of nodal disease were observed in two patients with extraosseous disease (overall response rate, 5%; 95% confidence interval, 0.64‐17.75%). The authors conclude that IFL‐RA cannot be recommended at this dose and schedule in patients with advanced prostate cancer, but additional study of its use in patients with nodal disease may be warranted. Cancer 1992; 702310‐2312.
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U2 - 10.1002/1097-0142(19921101)70:9<2310::AID-CNCR2820700916>3.0.CO;2-4
DO - 10.1002/1097-0142(19921101)70:9<2310::AID-CNCR2820700916>3.0.CO;2-4
M3 - Article
C2 - 1382829
AN - SCOPUS:0026661562
SN - 0008-543X
VL - 70
SP - 2310
EP - 2312
JO - Cancer
JF - Cancer
IS - 9
ER -