A Phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma

J. Rubin; A. J. Schutt; H. C. Pitot IV

doi:10.1097/00000421-199206000-00011

A Phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma

J. Rubin, A. J. Schutt, H. C. Pitot IV

Medical Oncology

Research output: Contribution to journal › Article › peer-review

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Abstract

Fifteen patients with advanced measurable colorectal carcinoma were treated with intravenous 6-thioguanine (6-TG) at a dosage of 55 mg/m² for 5 consecutive days every 5 weeks. Only one patient had received prior adjuvant chemotherapy. No responses were detected, and eight patients had stable disease for a median duration of three treatment cycles. Toxicity was tolerable. We conclude that 6-TG given by this dosage schedule is ineffective in treating metastatic colorectal carcinoma.

Original language	English (US)
Pages (from-to)	236-238
Number of pages	3
Journal	American Journal of Clinical Oncology: Cancer Clinical Trials
Volume	15
Issue number	3
DOIs	https://doi.org/10.1097/00000421-199206000-00011
State	Published - 1992

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "A Phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma",

abstract = "Fifteen patients with advanced measurable colorectal carcinoma were treated with intravenous 6-thioguanine (6-TG) at a dosage of 55 mg/m2 for 5 consecutive days every 5 weeks. Only one patient had received prior adjuvant chemotherapy. No responses were detected, and eight patients had stable disease for a median duration of three treatment cycles. Toxicity was tolerable. We conclude that 6-TG given by this dosage schedule is ineffective in treating metastatic colorectal carcinoma.",

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year = "1992",

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AB - Fifteen patients with advanced measurable colorectal carcinoma were treated with intravenous 6-thioguanine (6-TG) at a dosage of 55 mg/m2 for 5 consecutive days every 5 weeks. Only one patient had received prior adjuvant chemotherapy. No responses were detected, and eight patients had stable disease for a median duration of three treatment cycles. Toxicity was tolerable. We conclude that 6-TG given by this dosage schedule is ineffective in treating metastatic colorectal carcinoma.

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A Phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma

Abstract

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