TY - JOUR
T1 - A phase II study of cis‐diamminedichloroplatinum and 5‐fluorouracil in advanced upper aerodigestive neoplasms
AU - Creagan, Edward T.
AU - Ingle, James N.
AU - Schutt, Allan J.
AU - O'Fallon, Judith R.
PY - 1984
Y1 - 1984
N2 - Thirty patients with advanced head and neck cancer of diverse histologies received the combination of cis‐diamminedichloroplatinum (CDDP) (100 mg/m2) and 5‐fluorouracil (5‐FU) (1,000 mg/m2/24 hours × 4 days) at 3–4‐week intervals. Among all study participants, the median time to progression was 3.9 months and the median survival was 7.2 months. Among 20 patients with squamous cell carcinoma, we observed five objective regressions (25%). None of the responders had prior chemotherapy; four had extensive prior radiation therapy. Among 10 patients with non‐squamous cell carcinoma neoplasms, we detected three objective responses (30%). Histopathology of the responding patients included poorly differentiated sarcoma, anaplastic carcinoma, and malignant mixed parotid tumor. Significant gastrointestinal toxicities included moderate‐to‐severe nausea (60%), vomiting (43%), and stomatitis (57%). Leukopenia (< 4,000 cells/mm3) and thrombocytopenia (< 130,000 cells/mm3) affected 78% and 41% of patients, respectively, without sepsis or hemorrhage.
AB - Thirty patients with advanced head and neck cancer of diverse histologies received the combination of cis‐diamminedichloroplatinum (CDDP) (100 mg/m2) and 5‐fluorouracil (5‐FU) (1,000 mg/m2/24 hours × 4 days) at 3–4‐week intervals. Among all study participants, the median time to progression was 3.9 months and the median survival was 7.2 months. Among 20 patients with squamous cell carcinoma, we observed five objective regressions (25%). None of the responders had prior chemotherapy; four had extensive prior radiation therapy. Among 10 patients with non‐squamous cell carcinoma neoplasms, we detected three objective responses (30%). Histopathology of the responding patients included poorly differentiated sarcoma, anaplastic carcinoma, and malignant mixed parotid tumor. Significant gastrointestinal toxicities included moderate‐to‐severe nausea (60%), vomiting (43%), and stomatitis (57%). Leukopenia (< 4,000 cells/mm3) and thrombocytopenia (< 130,000 cells/mm3) affected 78% and 41% of patients, respectively, without sepsis or hemorrhage.
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U2 - 10.1002/hed.2890060607
DO - 10.1002/hed.2890060607
M3 - Article
C2 - 6540763
AN - SCOPUS:0021212934
SN - 0148-6403
VL - 6
SP - 1020
EP - 1023
JO - Head & Neck Surgery
JF - Head & Neck Surgery
IS - 6
ER -