A phase IB study of the pharmacokinetics of gemcitabine and pemetrexed, when administered in rapid sequence to patients with advanced solid tumors

Grace K. Dy, Ajit Suri, Joel M. Reid, Jeff A. Sloan, Henry C. Pitot, Steven R. Alberts, Richard M. Goldberg, Pamela J. Atherton, Lorelei J. Hanson, Patrick A. Burch, Joseph Rubin, Charles Erlichman, Alex A. Adjei

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: We have previously demonstrated that pemetrexed is clinically active when administered 90 min after gemcitabine in a phase I study. The present study was undertaken to evaluate the efficacy, toxicity, and pharmacokinetics of gemcitabine and pemetrexed when pemetrexed is administered immediately after gemcitabine. Patients and Methods: A total of 14 patients received 84 cycles of treatment. Gemcitabine 1250 mg/m2 was administered on days 1 and 8 of each 21-day cycle, and pemetrexed 500 mg/m 2 on day 8 immediately following gemcitabine administration. Toxicities were graded according to the National Cancer Institute Common Toxicity Criteria and recorded as maximum grade per patient for all treatment cycles. Pharmacokinetic analyses of plasma gemcitabine and pemetrexed concentrations were performed. Results: Neutropenia was the most common severe toxicity. Non-hematologic toxicities, which included nausea, vomiting, fatigue, diarrhea, rash, and elevated transaminases were of mild-to-moderate severity. No increased toxicity was observed with this schedule in comparison to the previous phase I schedule. There was no pharmacokinetic interaction between the two drugs. One partial response was documented in a patient with non-small-cell lung cancer. Eight patients had disease stabilization for five or more cycles. Conclusion: Gemcitabine immediately followed by pemetrexed is well tolerated and clinically active, and deserves further evaluation in phase II trials.

Original languageEnglish (US)
Pages (from-to)522-530
Number of pages9
JournalCancer chemotherapy and pharmacology
Volume55
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Combination chemotherapy
  • Gemcitabine
  • Pemetrexed
  • Pharmacokinetics
  • Schedule

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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