A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib with Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients

Wen Wee Ma, Hao Xie, Gerald Fetterly, Laura Pitzonka, Amy Whitworth, Charles Levea, John Wilton, Krystin Mantione, Sarah Schihl, Grace K. Dy, Patrick Boland, Renuka Iyer, Wei Tan, William Brady, Robert M. Straubinger, Alex A. Adjei

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives: Preclinical studies demonstrated antitumor activity of dovitinib in pancreatic cancer models. This phase Ib study aimed to determine the maximum tolerated dose (MTD) of dovitinib in combination with gemcitabine and capecitabine and to characterize the safety and pharmacokinetic profile in patients with advanced pancreatic and biliary tract cancers and solid malignancies. Materials and Methods: Patients received gemcitabine 1000 mg/m intravenously on days 1 and 8, capecitabine 1300 mg/m oral daily from day 1 to 14, and dovitinib oral daily 5 days on and 2 days off, every 21-day cycle. The standard 3+3 dose escalation design was utilized and the study expanded to treat an additional 20 advanced pancreatic and biliary tract cancers patients at MTD. Results: A total of 29 patients were enrolled. One patient experienced dose-limiting grade 3 colitis. Two patients developed clinically significant neuropathy after the first cycle requiring dose reduction. The MTD was not reached and dovitinib 300 mg was declared the recommended dose for expansion. The most frequent grade 2 or worse adverse events were fatigue (45%), neutropenia (41%), thrombocytopenia (34%), anemia (24%), nausea (24%), and palmer-plantar erythrodysaesthesia syndrome (21%). Partial responses were observed in 5 patients. Pharmacokinetic studies showed no drug-drug interaction between dovitinib, capecitabine and gemcitabine. Fibroblast growth factor 23 plasma level increased in 4 of 5 patients during the first cycle of treatment. Conclusions: Dovitinib 300 mg daily is the recommended dose when combined with gemcitabine and capecitabine, achieving clinically relevant plasma concentrations. The study combination demonstrated encouraging efficacy signals in advanced pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • FGFR/VEGFR inhibitor
  • dovitinib
  • pancreatic adenocarcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib with Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients'. Together they form a unique fingerprint.

  • Cite this

    Ma, W. W., Xie, H., Fetterly, G., Pitzonka, L., Whitworth, A., Levea, C., Wilton, J., Mantione, K., Schihl, S., Dy, G. K., Boland, P., Iyer, R., Tan, W., Brady, W., Straubinger, R. M., & Adjei, A. A. (2019). A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib with Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients. American Journal of Clinical Oncology: Cancer Clinical Trials, 42(2), 184-189. https://doi.org/10.1097/COC.0000000000000492