A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors

Tufia Haddad, Rui Qin, Ruth Lupu, Daniel Satele, Matthew Eadens, Matthew P. Goetz, Charles Erlichman, Julian Molina

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Purpose: Cilengitide is a potent and selective inhibitor of the integrins αvβ3 and αvβ5. The primary objective of this phase I clinical trial was to establish the maximum tolerated dose and determine safety/tolerability of cilengitide in combination with paclitaxel in patients with advanced solid tumors. Secondary objectives included the evaluation of the preliminary clinical outcomes. Patients and methods: Patients with advanced solid tumors experiencing disease progression on standard treatment were assigned to two different dose levels of cilengitide (2000 mg intravenously once or twice weekly) in combination with fixed-dose, weekly paclitaxel (90 mg/m2 intravenously). Results: Twelve evaluable patients were treated per protocol. A single dose limiting toxicity (DLT) of grade 4 neutropenia was observed at the starting dose level of once weekly cilengitide. There were no grade ≥3 adverse events that occurred with >10% frequency. One patient achieved a partial response to therapy. Five patients experienced stable disease as best response, 3 of which discontinued study participation due to progressive, peripheral neuropathy. Conclusions: Cilengitide in combination with paclitaxel was well tolerated. Antitumor activity was observed. The recommended phase II dose is twice weekly cilengitide (2000 mg) with weekly paclitaxel (90 mg/m2). Further studies evaluating drugs that target this pathway are warranted.

Original languageEnglish (US)
Pages (from-to)1221-1227
Number of pages7
JournalCancer Chemotherapy and Pharmacology
Volume79
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • Cilengitide
  • Paclitaxel
  • Solid tumors
  • Αvβ3 and αvβ5 integrins

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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