A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases

Jeffrey J. Meyer, Ryan D. Foster, Naama Lev-Cohain, Takeshi Yokoo, Ying Dong, Roderich E. Schwarz, William Rule, Jing Tian, Yang Xie, Raquibul Hannan, Lucien Nedzi, Timothy Solberg, Robert Timmerman

Research output: Contribution to journalArticle

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Abstract

Background: There is significant interest in the use of stereotactic ablative radiotherapy (SABR) as a treatment modality for liver metastases. A variety of SABR fractionation schemes are in clinical use. We conducted a phase I dose-escalation study to determine the maximum tolerated dose of single-fraction liver SABR. Methods: Patients with liver metastases from solid tumors, for whom a critical volume dose constraint could be met, were treated with single-fraction SABR. Seven patients were enrolled to the first group, with a prescription dose of 35 Gy. Dose was then escalated to 40 Gy in a single fraction, and seven more patients were treated at this dose level. Patients were followed for toxicity and underwent serial imaging to assess lesion response and local control. Results: Fourteen patients with 17 liver metastases were treated. There were no dose-limiting toxicities observed at either dose level. Nine of the 13 lesions assessable for treatment response showed a complete radiographic response to treatment; the remainder showed partial response. Local control of irradiated lesions was 100 % at a median imaging follow-up of 2.5 years. Two-year overall survival for all patients was 78 %. Conclusions: For selected patients with liver metastases, single-fraction SABR at doses of 35 and 40 Gy is tolerable and shows promising signs of efficacy at intermediate follow-up.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalAnnals of Surgical Oncology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2016

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Radiotherapy
Neoplasm Metastasis
Liver
Maximum Tolerated Dose
Prescriptions
Therapeutics
Survival
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Meyer, J. J., Foster, R. D., Lev-Cohain, N., Yokoo, T., Dong, Y., Schwarz, R. E., ... Timmerman, R. (2016). A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases. Annals of Surgical Oncology, 23(1), 218-224. https://doi.org/10.1245/s10434-015-4579-z

A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases. / Meyer, Jeffrey J.; Foster, Ryan D.; Lev-Cohain, Naama; Yokoo, Takeshi; Dong, Ying; Schwarz, Roderich E.; Rule, William; Tian, Jing; Xie, Yang; Hannan, Raquibul; Nedzi, Lucien; Solberg, Timothy; Timmerman, Robert.

In: Annals of Surgical Oncology, Vol. 23, No. 1, 01.01.2016, p. 218-224.

Research output: Contribution to journalArticle

Meyer, JJ, Foster, RD, Lev-Cohain, N, Yokoo, T, Dong, Y, Schwarz, RE, Rule, W, Tian, J, Xie, Y, Hannan, R, Nedzi, L, Solberg, T & Timmerman, R 2016, 'A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases', Annals of Surgical Oncology, vol. 23, no. 1, pp. 218-224. https://doi.org/10.1245/s10434-015-4579-z
Meyer, Jeffrey J. ; Foster, Ryan D. ; Lev-Cohain, Naama ; Yokoo, Takeshi ; Dong, Ying ; Schwarz, Roderich E. ; Rule, William ; Tian, Jing ; Xie, Yang ; Hannan, Raquibul ; Nedzi, Lucien ; Solberg, Timothy ; Timmerman, Robert. / A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases. In: Annals of Surgical Oncology. 2016 ; Vol. 23, No. 1. pp. 218-224.
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AU - Dong, Ying

AU - Schwarz, Roderich E.

AU - Rule, William

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