Abstract
Despite response rates of 30% after high-dose chemotherapy with autologous hematopoietic stem cell transplant, patients with multiple myeloma are not cured. 153Samarium ethylenediaminetetramethylenephosphonate (153Sm-EDTMP; Quadramet®) is a short-range, β-emitting therapeutic radiopharmaceutical with avid skeletal uptake. In total, 12 patients were treated with escalating doses of 153Sm-EDTMP (N=3/group; 6, 12, 19.8, and 30 mCi/kg) and a fixed dose of melphalan (200 mg/m2). No dose limiting toxicity was seen. To better standardize the marrow compartment radiation dose, the study was modified such that an additional six patients were treated at a targeted absorbed radiation dose to the red marrow of 40 Gy based on a trace labeled infusion 1 week prior to the therapy. Despite rapid elimination of unbound radiopharmaceutical via kidneys and bladder, no episodes of nephrotoxicity, hemorrhagic cystitis, or delayed radiation nephritis were observed with a median follow-up of 31 months (range 8.5-44). Median times to ANC>0.5 and platelet >20 × 106/I were 12 and 11 days, respectively, with no graft failures. Overall response rate was 94% including seven very good artial responses and five complete responses. Addition of 153Sm EDTMP to melphalan conditioning appears to be safe, well-tolerated and worthy of further study.
Original language | English (US) |
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Pages (from-to) | 118-125 |
Number of pages | 8 |
Journal | Leukemia |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2005 |
Keywords
- Bone marrow
- Multiple myeloma
- Quadramet®
- Radiation
- Samarium
- Stem cell transplant
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research