A pharmacological challenge predicts reversible rectal sensorimotor dysfunctions in women with fecal incontinence

M. Sharma, K. Feuerhak, A. R. Zinsmeister, Adil Eddie Bharucha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: In order to understand the pathophysiology of rectal sensorimotor dysfunctions in women with fecal incontinence (FI) and rectal urgency, we evaluated the effects of a muscarinic antagonist and an adrenergic α2 agonist on these parameters. Methods: Firstly, rectal distensibility and sensation were evaluated with a barostat and sinusoidal oscillation at baseline and after randomization to intravenous saline or atropine in 16 healthy controls and 44 FI patients. Thereafter, FI patients were randomized to placebo or clonidine for 4 wk; rectal compliance and sensation were revaluated thereafter. The effect of atropine and clonidine on rectal functions and the relationship between them were evaluated. Results: At baseline, compared to controls, rectal capacity was lower (P =.03) while the mean pressure (P =.02) and elastance (P =.01) during sinusoidal oscillation were greater, signifying reduced distensibility, in FI. Compared to placebo, atropine increased (P ≤.02) the heart rate in controls and FI and reduced (P =.03) the variability in rectal pressures during sinusoidal oscillation in controls. Clonidine increased rectal compliance (P =.04) and reduced rectal capacity (P =.03) in FI. The effects of atropine and clonidine on compliance (r =.44, P =.003), capacity (r =.34, P =.02), pressures during sinusoidal oscillation (r =.3, P =.057), pressure (r =.6, P <.0001), and volume sensory thresholds (r =.48, P =.003) were correlated. Conclusions: The effects of atropine and clonidine on rectal distensibility and sensation were significantly correlated. A preserved response to atropine suggests that reduced rectal distensibility is partly reversible, mediated by cholinergic mechanisms, and may predict the response to clonidine, providing a pharmacological challenge.

Original languageEnglish (US)
Article numbere13383
JournalNeurogastroenterology and Motility
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Fecal Incontinence
Clonidine
Atropine
Pharmacology
Compliance
Pressure
Placebos
Sensory Thresholds
Adrenergic Agonists
Muscarinic Antagonists
Random Allocation
Cholinergic Agents
Heart Rate

Keywords

  • atropine
  • clonidine
  • fecal incontinence
  • rectal capacity
  • rectal compliance
  • urgency

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

A pharmacological challenge predicts reversible rectal sensorimotor dysfunctions in women with fecal incontinence. / Sharma, M.; Feuerhak, K.; Zinsmeister, A. R.; Bharucha, Adil Eddie.

In: Neurogastroenterology and Motility, Vol. 30, No. 10, e13383, 01.10.2018.

Research output: Contribution to journalArticle

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