A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction

Jelena R. Ghadri; Svetlana Dougoud; Willibald Maier; Philipp A. Kaufmann; Oliver Gaemperli; Abhiram Prasad; Thomas F. Lüscher; Christian Templin

doi:10.1007/s10554-013-0311-x

A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction

Jelena R. Ghadri, Svetlana Dougoud, Willibald Maier, Philipp A. Kaufmann, Oliver Gaemperli, Abhiram Prasad, Thomas F. Lüscher, Christian Templin

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Takotsubo cardiomyopathy (TTC) is still an under-recognized disease and little data exists on the coexistence of TTC and obstructive coronary artery disease. Our patient case of an 80-year-old female lady highlights the impact of a positron emission tomography/ computed tomography (PET/CT) follow-up imaging study to delineate this unique entity from acute coronary syndrome (ACS). Furthermore, we show for the first time that coronary flow reserve and myocardial blood flow is globally impaired in TTC and not only restricted to the noncontracting parts. This indicates a global microcirculatory impairment effect of the heart in the acute stage of TTC. Our case also demonstrates that a transient metabolic defect is also involved in this disease. Follow-up imaging by PET/CT in our patient case unmasked TTC and facilitated to exclude the differential diagnosis of ACS.

Original language	English (US)
Pages (from-to)	207-209
Number of pages	3
Journal	International Journal of Cardiovascular Imaging
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/s10554-013-0311-x
State	Published - Jan 2014

Keywords

Acute coronary syndrome
PET/CT-imaging
Takotsubo cardiomyopathy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s10554-013-0311-x

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title = "A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction",

abstract = "Takotsubo cardiomyopathy (TTC) is still an under-recognized disease and little data exists on the coexistence of TTC and obstructive coronary artery disease. Our patient case of an 80-year-old female lady highlights the impact of a positron emission tomography/ computed tomography (PET/CT) follow-up imaging study to delineate this unique entity from acute coronary syndrome (ACS). Furthermore, we show for the first time that coronary flow reserve and myocardial blood flow is globally impaired in TTC and not only restricted to the noncontracting parts. This indicates a global microcirculatory impairment effect of the heart in the acute stage of TTC. Our case also demonstrates that a transient metabolic defect is also involved in this disease. Follow-up imaging by PET/CT in our patient case unmasked TTC and facilitated to exclude the differential diagnosis of ACS.",

keywords = "Acute coronary syndrome, PET/CT-imaging, Takotsubo cardiomyopathy",

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doi = "10.1007/s10554-013-0311-x",

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AU - Ghadri, Jelena R.

AU - Dougoud, Svetlana

AU - Maier, Willibald

AU - Kaufmann, Philipp A.

AU - Gaemperli, Oliver

AU - Prasad, Abhiram

AU - Lüscher, Thomas F.

AU - Templin, Christian

PY - 2014/1

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N2 - Takotsubo cardiomyopathy (TTC) is still an under-recognized disease and little data exists on the coexistence of TTC and obstructive coronary artery disease. Our patient case of an 80-year-old female lady highlights the impact of a positron emission tomography/ computed tomography (PET/CT) follow-up imaging study to delineate this unique entity from acute coronary syndrome (ACS). Furthermore, we show for the first time that coronary flow reserve and myocardial blood flow is globally impaired in TTC and not only restricted to the noncontracting parts. This indicates a global microcirculatory impairment effect of the heart in the acute stage of TTC. Our case also demonstrates that a transient metabolic defect is also involved in this disease. Follow-up imaging by PET/CT in our patient case unmasked TTC and facilitated to exclude the differential diagnosis of ACS.

AB - Takotsubo cardiomyopathy (TTC) is still an under-recognized disease and little data exists on the coexistence of TTC and obstructive coronary artery disease. Our patient case of an 80-year-old female lady highlights the impact of a positron emission tomography/ computed tomography (PET/CT) follow-up imaging study to delineate this unique entity from acute coronary syndrome (ACS). Furthermore, we show for the first time that coronary flow reserve and myocardial blood flow is globally impaired in TTC and not only restricted to the noncontracting parts. This indicates a global microcirculatory impairment effect of the heart in the acute stage of TTC. Our case also demonstrates that a transient metabolic defect is also involved in this disease. Follow-up imaging by PET/CT in our patient case unmasked TTC and facilitated to exclude the differential diagnosis of ACS.

KW - Acute coronary syndrome

KW - PET/CT-imaging

KW - Takotsubo cardiomyopathy

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A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

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