A patient with nephrotic-range proteinuria and focal global glomerulosclerosis

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Abstract

A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecularweight proteins. The case illustrates the crucial role of electron microscopy aswell as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.

Original languageEnglish (US)
Pages (from-to)1979-1987
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume8
Issue number11
DOIs
StatePublished - Nov 7 2013

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Focal Segmental Glomerulosclerosis
Proteinuria
Biopsy
Hypercalciuria
Nephrotic Syndrome
Creatinine
Electron Microscopy
Kidney
Serum
Proteins

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

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abstract = "A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecularweight proteins. The case illustrates the crucial role of electron microscopy aswell as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.",
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