A patient with established primary progressive multiple sclerosis transitions to 'secondary' relapsing-remitting disease course following a fulminant demyelinating episode

Melih Tutuncu, Nuri O. Demirci, Feriha Özer, Sabahattin Saip, Orhun H. Kantarci, Aksel Siva

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Primary progressive multiple sclerosis (PPMS), relapsing remitting MS (RRMS) and acute disseminated encephalomyelitis (ADEM) are clinically and immunopathogenetically distinct phenotypes of inflammatory demyelinating disorders of the central nervous system. Progression following RRMS is well described as secondary progressive MS. We report a patient with unexpected transition from long established PPMS to clinically and radiologically active RRMS after an ADEM-like fulminant demyelinating episode despite an immunosuppressive treatment preceding relapses. We note clearly accelerated brain atrophy after the RRMS course ensues. The unique disease course in this patient illustrates the dissociation of the biology and disability impact of relapses and progression.

Original languageEnglish (US)
Pages (from-to)1262-1264
Number of pages3
JournalMultiple Sclerosis Journal
Volume17
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Fulminant
  • multiple sclerosis
  • progressive

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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