TY - JOUR
T1 - A pathway map of glutamate metabolism
AU - Yelamanchi, Soujanya D.
AU - Jayaram, Savita
AU - Thomas, Joji Kurian
AU - Gundimeda, Seetaramanjaneyulu
AU - Khan, Aafaque Ahmad
AU - Singhal, Anish
AU - Keshava Prasad, T. S.
AU - Pandey, Akhilesh
AU - Somani, B. L.
AU - Gowda, Harsha
N1 - Funding Information:
We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Soujanya D. Yelamanchi is a recipient of a Senior Research Fellowship from the Department of Science and Technology (DST), Government of India. Aafaque Ahmad Khan is a recipient of a Senior Research Fellowship from Indian Council of Medical Research (ICMR).
Publisher Copyright:
© 2015, The International CCN Society.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.
AB - Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.
KW - Activators
KW - Feedback regulation
KW - Glutamine and inhibitors
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U2 - 10.1007/s12079-015-0315-5
DO - 10.1007/s12079-015-0315-5
M3 - Article
AN - SCOPUS:84949508058
SN - 1873-9601
VL - 10
SP - 69
EP - 75
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 1
ER -