A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.

Rajiv Kumar, Mark R. Pittelkow, Jeffrey L. Salisbury, Joseph P. Grande, Hee Jeong Im, Kathrin A. Feldmann, David Schilling

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

Original languageEnglish (US)
Pages (from-to)123-134
Number of pages12
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume164
StatePublished - 2003

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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