A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.

Rajiv Kumar, Mark R. Pittelkow, Jeffrey L Salisbury, Joseph Peter Grande, Hee Jeong Im, Kathrin A. Feldmann, David Schilling

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

Original languageEnglish (US)
Pages (from-to)123-134
Number of pages12
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume164
StatePublished - 2003

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Immediate-Early Genes
Vitamin D
Apoptosis
Response Elements
Sterols
Growth
Messenger RNA
DNA
dihydroxy-vitamin D3

Cite this

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title = "A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.",
abstract = "1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.",
author = "Rajiv Kumar and Pittelkow, {Mark R.} and Salisbury, {Jeffrey L} and Grande, {Joseph Peter} and Im, {Hee Jeong} and Feldmann, {Kathrin A.} and David Schilling",
year = "2003",
language = "English (US)",
volume = "164",
pages = "123--134",
journal = "Recent Results in Cancer Research",
issn = "0080-0015",
publisher = "Springer New York",

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TY - JOUR

T1 - A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.

AU - Kumar, Rajiv

AU - Pittelkow, Mark R.

AU - Salisbury, Jeffrey L

AU - Grande, Joseph Peter

AU - Im, Hee Jeong

AU - Feldmann, Kathrin A.

AU - Schilling, David

PY - 2003

Y1 - 2003

N2 - 1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

AB - 1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

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VL - 164

SP - 123

EP - 134

JO - Recent Results in Cancer Research

JF - Recent Results in Cancer Research

SN - 0080-0015

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