A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm

Joanna C. Dalland, Patrick R. Blackburn, Kaaren K. Reichard, Sarah H. Johnson, James B. Smadbeck, George Vasmatzis, Nicole L. Hoppman, Xinjie Xu, Patricia T. Greipp, Linda B. Baughn, Jess F. Peterson

Research output: Contribution to journalArticlepeer-review

Abstract

The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.

Original languageEnglish (US)
Pages (from-to)e134-e138
JournalLaboratory medicine
Volume53
Issue number5
DOIs
StatePublished - Sep 1 2022

Keywords

  • PDGFRA
  • USP25
  • eosinophilia
  • mate-pair sequencing
  • next-generation sequencing

ASJC Scopus subject areas

  • Medicine(all)

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