A novel report of cIg-FISH and cytogenetics in POEMS syndrome

Alan H. Bryce, Rhett P. Ketterling, Morie A. Gertz, Martha Lacy, Ryan A. Knudson, Shaji Kumar, Robert A. Kyle, Rafael Fonseca, Phillip R. Greipp, John A. Lust, Vincent S. Rajkumar, Suzanne R. Hayman, Francis Buadi, Stephen J. Russell, Stephen R. Zeldenrust, Angela Dispenzieri

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.

Original languageEnglish (US)
Pages (from-to)840-841
Number of pages2
JournalAmerican journal of hematology
Volume83
Issue number11
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Hematology

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