A novel pacemaker mechanism drives gastrointestinal rhythmicity

Kenton M. Sanders, Tamás Ördög, Sang Don Koh, Sean M. Ward

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca2+ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalNews in Physiological Sciences
Volume15
Issue number6
DOIs
StatePublished - Dec 2000

ASJC Scopus subject areas

  • Physiology

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