A novel pacemaker mechanism drives gastrointestinal rhythmicity

Kenton M. Sanders, Tamas Ordog, Sang Don Koh, Sean M. Ward

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca2+ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalNews in Physiological Sciences
Volume15
Issue number6
StatePublished - Dec 2000
Externally publishedYes

Fingerprint

Interstitial Cells of Cajal
Periodicity
Endoplasmic Reticulum
Gastrointestinal Tract
Cations
Mitochondria
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Sanders, K. M., Ordog, T., Koh, S. D., & Ward, S. M. (2000). A novel pacemaker mechanism drives gastrointestinal rhythmicity. News in Physiological Sciences, 15(6), 291-298.

A novel pacemaker mechanism drives gastrointestinal rhythmicity. / Sanders, Kenton M.; Ordog, Tamas; Koh, Sang Don; Ward, Sean M.

In: News in Physiological Sciences, Vol. 15, No. 6, 12.2000, p. 291-298.

Research output: Contribution to journalArticle

Sanders, KM, Ordog, T, Koh, SD & Ward, SM 2000, 'A novel pacemaker mechanism drives gastrointestinal rhythmicity', News in Physiological Sciences, vol. 15, no. 6, pp. 291-298.
Sanders, Kenton M. ; Ordog, Tamas ; Koh, Sang Don ; Ward, Sean M. / A novel pacemaker mechanism drives gastrointestinal rhythmicity. In: News in Physiological Sciences. 2000 ; Vol. 15, No. 6. pp. 291-298.
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