A novel pacemaker mechanism drives gastrointestinal rhythmicity

Kenton M. Sanders; Tamás Ördög; Sang Don Koh; Sean M. Ward

doi:10.1152/physiologyonline.2000.15.6.291

A novel pacemaker mechanism drives gastrointestinal rhythmicity

Kenton M. Sanders, Tamás Ördög, Sang Don Koh, Sean M. Ward

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca²⁺ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.

Original language	English (US)
Pages (from-to)	291-298
Number of pages	8
Journal	News in Physiological Sciences
Volume	15
Issue number	6
DOIs	https://doi.org/10.1152/physiologyonline.2000.15.6.291
State	Published - Dec 2000

ASJC Scopus subject areas

Physiology

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10.1152/physiologyonline.2000.15.6.291

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abstract = "Electric pacemaker activity drives peristaltic and segmental contractions in the gastrointestinal tract. Interstitial cells of Cajal (ICC) are responsible for spontaneous pacemaker activity. ICC remain rhythmic in culture and generate voltage-independent inward currents via a nonselective cation conductance. Ca2+ release from endoplasmic reticulum and uptake by mitochondria initiates pacemaker currents. This novel mechanism provides the basis for electric rhythmicity in gastrointestinal muscles.",

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A novel pacemaker mechanism drives gastrointestinal rhythmicity

Abstract

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