TY - JOUR
T1 - A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity
AU - Boules, Mona
AU - Warrington, Lewis
AU - Fauq, Abdul
AU - McCormick, Daniel
AU - Richelson, Elliott
N1 - Funding Information:
This work was supported by the Mayo Foundation for Medical Education and Research and by grant MH 27692 from the National Institute of Mental Health.
PY - 2001/8/24
Y1 - 2001/8/24
N2 - Neurotensin is a tridecapeptide that exhibits selective anatomic and neurochemical interactions with dopaminergic systems. Since dopaminergic neurotransmission underlies many of the behavioral properties of psychostimulants, and since neurotensin has been implicated in modulating dopaminergic neurotransmitter systems, we tested the effect of our novel neurotensin analog, NT69L (N-methyl-Arg8,L-Lys9,L-neo-Trp11, tert-Leu12]neurotensin-(8-13)), on hyperactivity caused by cocaine and D-amphetamine. Previously, we showed that NT69L reduces body temperature, blocks apomorphine-induced climbing, and haloperidol-induced catalepsy. In this study, NT69L blocked the hyperactivity induced by both cocaine and D-amphetamine administered at three different doses each, when this peptide was injected intraperitoneally. These results provide further evidence for the involvement of the neurotensin system in some of the behavioral properties of psychostimulants and suggest that NT69L may find clinical application in patients who abuse this class of compounds.
AB - Neurotensin is a tridecapeptide that exhibits selective anatomic and neurochemical interactions with dopaminergic systems. Since dopaminergic neurotransmission underlies many of the behavioral properties of psychostimulants, and since neurotensin has been implicated in modulating dopaminergic neurotransmitter systems, we tested the effect of our novel neurotensin analog, NT69L (N-methyl-Arg8,L-Lys9,L-neo-Trp11, tert-Leu12]neurotensin-(8-13)), on hyperactivity caused by cocaine and D-amphetamine. Previously, we showed that NT69L reduces body temperature, blocks apomorphine-induced climbing, and haloperidol-induced catalepsy. In this study, NT69L blocked the hyperactivity induced by both cocaine and D-amphetamine administered at three different doses each, when this peptide was injected intraperitoneally. These results provide further evidence for the involvement of the neurotensin system in some of the behavioral properties of psychostimulants and suggest that NT69L may find clinical application in patients who abuse this class of compounds.
KW - Cocaine
KW - D-Amphetamine
KW - Hyperactivity
KW - Neurotensin
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U2 - 10.1016/S0014-2999(01)01197-9
DO - 10.1016/S0014-2999(01)01197-9
M3 - Article
C2 - 11525773
AN - SCOPUS:0035943375
SN - 0014-2999
VL - 426
SP - 73
EP - 76
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -