A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis

Yunyan Zhang, Jennifer Wells, Richard Buist, James Peeling, V. Wee Yong, Joseph Ross Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a novel multiscale localized image texture analysis technique, based upon the polar Stockwell Transform (PST). In this paper we characterized image texture in vivo using the PST in historically verified lesion areas in T2-weighted MRI of an animal model of multiple sclerosis. Both high and low frequency signals, representing inflammation and demyelination, were significantly increased in pathological regions compared to normal control tissue. This suggests that this new local spatial-frequency measure of image texture may provide a sensitive and precise indication of disease activity.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages760-767
Number of pages8
Volume4190 LNCS - I
StatePublished - 2006
Externally publishedYes
Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen, Denmark
Duration: Oct 1 2006Oct 6 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4190 LNCS - I
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
CountryDenmark
CityCopenhagen
Period10/1/0610/6/06

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

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  • Cite this

    Zhang, Y., Wells, J., Buist, R., Peeling, J., Yong, V. W., & Mitchell, J. R. (2006). A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4190 LNCS - I, pp. 760-767). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4190 LNCS - I).