A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis

Yunyan Zhang, Jennifer Wells, Richard Buist, James Peeling, V. Wee Yong, J. Ross Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Scopus citations

Abstract

We have developed a novel multiscale localized image texture analysis technique, based upon the polar Stockwell Transform (PST). In this paper we characterized image texture in vivo using the PST in historically verified lesion areas in T2-weighted MRI of an animal model of multiple sclerosis. Both high and low frequency signals, representing inflammation and demyelination, were significantly increased in pathological regions compared to normal control tissue. This suggests that this new local spatial-frequency measure of image texture may provide a sensitive and precise indication of disease activity.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings
PublisherSpringer Verlag
Pages760-767
Number of pages8
ISBN (Print)3540447075, 9783540447078
StatePublished - Jan 1 2006
Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen, Denmark
Duration: Oct 1 2006Oct 6 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4190 LNCS - I
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
CountryDenmark
CityCopenhagen
Period10/1/0610/6/06

    Fingerprint

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Zhang, Y., Wells, J., Buist, R., Peeling, J., Yong, V. W., & Mitchell, J. R. (2006). A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings (pp. 760-767). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4190 LNCS - I). Springer Verlag.