Abstract
We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.
Original language | English (US) |
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Pages (from-to) | 116-122 |
Number of pages | 7 |
Journal | Epilepsy Research |
Volume | 96 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2011 |
Keywords
- Canine
- EEG
- Epilepsy device
- Intracranial
ASJC Scopus subject areas
- Neurology
- Clinical Neurology