A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing

David M. Sletten, Kurt Kimpinski, Stephen D. Weigand, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume150
Issue number1-2
DOIs
StatePublished - Oct 5 2009

Keywords

  • Acetylcholine
  • Gel
  • Iontophoresis
  • QSART
  • Solution
  • Vehicle

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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