A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing

David M. Sletten; Kurt Kimpinski; Stephen D. Weigand; Phillip A. Low

doi:10.1016/j.autneu.2009.05.250

A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing

David M. Sletten, Kurt Kimpinski, Stephen D. Weigand, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	150
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2009.05.250
State	Published - Oct 5 2009

Keywords

Acetylcholine
Gel
Iontophoresis
QSART
Solution
Vehicle

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1016/j.autneu.2009.05.250

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title = "A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing",

abstract = "This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.",

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author = "Sletten, {David M.} and Kurt Kimpinski and Weigand, {Stephen D.} and Low, {Phillip A.}",

note = "Funding Information: We would like to thank Dr. Arnold Lindall and Terri Martin for their expertise in helping develop the gel formulation. We would like to also thank Toni Gehrking and Jade Gehrking for their technical assistance. This work was supported by NIH grants (NS3 2352, NS4 4233, NS4 3364, UL1 RR24150) and Mayo Clinic. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. ",

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AU - Kimpinski, Kurt

AU - Weigand, Stephen D.

AU - Low, Phillip A.

N1 - Funding Information: We would like to thank Dr. Arnold Lindall and Terri Martin for their expertise in helping develop the gel formulation. We would like to also thank Toni Gehrking and Jade Gehrking for their technical assistance. This work was supported by NIH grants (NS3 2352, NS4 4233, NS4 3364, UL1 RR24150) and Mayo Clinic. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.

PY - 2009/10/5

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N2 - This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

AB - This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

KW - Acetylcholine

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KW - Iontophoresis

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KW - Solution

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A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing

Abstract

Keywords

ASJC Scopus subject areas

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