A novel computer adaptive word list memory test optimized for remote assessment: Psychometric properties and associations with neurodegenerative biomarkers in older women without dementia

Nikki H. Stricker, John L. Stricker, Aimee J. Karstens, Jennifer R. Geske, Julie A Fields, Jason Hassenstab, Christopher Schwarz, Nirubol Tosakulwong, Heather J. Wiste, Clifford R Jr. Jack, Kejal Kantarci, Michelle M Mielke

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: This study established the psychometric properties and preliminary validity of the Stricker Learning Span (SLS), a novel computer adaptive word list memory test designed for remote assessment and optimized for smartphone use. Methods: Women enrolled in the Mayo Clinic Specialized Center of Research Excellence (SCORE) were recruited via e-mail or phone to complete two remote cognitive testing sessions. Convergent validity was assessed through correlation with previously administered in-person neuropsychological tests (n = 96, ages 55–79) and criterion validity through associations with magnetic resonance imaging measures of neurodegeneration sensitive to Alzheimer's disease (n = 47). Results: SLS performance significantly correlated with the Auditory Verbal Learning Test and measures of neurodegeneration (temporal meta-regions of interest and entorhinal cortical thickness, adjusting for age and education). Test–retest reliabilities across two sessions were 0.71–0.76 (two-way mixed intraclass correlation coefficients). Discussion: The SLS is a valid and reliable self-administered memory test that shows promise for remote assessment of aging and neurodegenerative disorders.

Original languageEnglish (US)
Article numbere12299
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume14
Issue number1
DOIs
StatePublished - 2022

Keywords

  • aging
  • Alzheimer's disease
  • cortical thickness
  • entorhinal cortex
  • hippocampus
  • learning
  • Mayo Test Drive
  • mobile health
  • reliability
  • smartphone
  • Stricker Learning Span
  • Symbols Test
  • validity
  • web

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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