@article{e3512c7b718449959c7f1941c5c43e04,
title = "A novel computer adaptive word list memory test optimized for remote assessment: Psychometric properties and associations with neurodegenerative biomarkers in older women without dementia",
abstract = "Introduction: This study established the psychometric properties and preliminary validity of the Stricker Learning Span (SLS), a novel computer adaptive word list memory test designed for remote assessment and optimized for smartphone use. Methods: Women enrolled in the Mayo Clinic Specialized Center of Research Excellence (SCORE) were recruited via e-mail or phone to complete two remote cognitive testing sessions. Convergent validity was assessed through correlation with previously administered in-person neuropsychological tests (n = 96, ages 55–79) and criterion validity through associations with magnetic resonance imaging measures of neurodegeneration sensitive to Alzheimer's disease (n = 47). Results: SLS performance significantly correlated with the Auditory Verbal Learning Test and measures of neurodegeneration (temporal meta-regions of interest and entorhinal cortical thickness, adjusting for age and education). Test–retest reliabilities across two sessions were 0.71–0.76 (two-way mixed intraclass correlation coefficients). Discussion: The SLS is a valid and reliable self-administered memory test that shows promise for remote assessment of aging and neurodegenerative disorders.",
keywords = "aging, Alzheimer's disease, cortical thickness, entorhinal cortex, hippocampus, learning, Mayo Test Drive, mobile health, reliability, smartphone, Stricker Learning Span, Symbols Test, validity, web",
author = "Stricker, {Nikki H.} and Stricker, {John L.} and Karstens, {Aimee J.} and Geske, {Jennifer R.} and Fields, {Julie A} and Jason Hassenstab and Christopher Schwarz and Nirubol Tosakulwong and Wiste, {Heather J.} and Jack, {Clifford R Jr.} and Kejal Kantarci and Mielke, {Michelle M}",
note = "Funding Information: NHS, KK, and MMMi serve as consultants to Biogen, and MMMi serves as a consultant to the Brain Protection Company, outside the scope of this work. KK receives research support from Avid and Eli Lilly, outside the scope of this work. CRJ serves on an independent data monitoring board for Roche, has served as a speaker for Eisai, and consulted for Biogen, but he receives no personal compensation from any commercial entity. CRJ receives research support from NIH, the GHR Foundation, and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. JH is a paid consultant for Lundbeck, Biogen, Roche, and Takeda, outside the scope of this work. A Mayo Clinic invention disclosure has been submitted for the Stricker Learning Span and the Mayo Test Drive platform (NHS, JLS). AJK, JRG, JAF, JH, CGS, NT, HJW, CRJ, KK, and MMM have no disclosures related to the content of this submission. Funding Information: The authors wish to thank the participants and staff at the Specialized Center of Research Excellence (SCORE) on Sex Differences study. Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R21AG073967, U54 AG44170, R01AG057840 and the Rochester Epidemiology Project (R01 AG034676). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by the Kevin Merszei Career Development Award in Neurodegenerative Diseases Research IHO Janet Vittone, MD. Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",
year = "2022",
doi = "10.1002/dad2.12299",
language = "English (US)",
volume = "14",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}