A New TDA-based machine learning Classifier Framework for Predicting Hepatic Decompensation from MR Images

Yashbir Singh, William Jons, John E. Eaton, Joseph D. Sobek, Jaidip Jagtap, Gian Marco Conte, Eric G. Fuemmeler, Kuan Zhang, Yujia Wei, Diana Victoria Vera Garcia, Bradley J. Erickson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Machine-learning-based solutions need sufficient manually labeled training data to produce accurate predictions, which can hinder their performance for rare diseases with limited data. We show how to use a newly developed algebraic topology-based machine learning method that analyzes the visual pattern of the data to accurately predict hepatic decompensation in patients with Primary Sclerosing Cholangitis. The results demonstrate that the proposed methodology discriminates between Early Decompensation and Not Early groups. We found that the algebraic topology-based machinelearning approach allows us to make accurate predictions from small datasets such as predicting early and not early hepatic decompensation.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2022
Subtitle of host publicationImaging Informatics for Healthcare, Research, and Applications
EditorsThomas M. Deserno, Thomas M. Deserno, Brian J. Park
PublisherSPIE
ISBN (Electronic)9781510649491
DOIs
StatePublished - 2022
EventMedical Imaging 2022: Imaging Informatics for Healthcare, Research, and Applications - Virtual, Online
Duration: Mar 21 2022Mar 27 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12037
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2022: Imaging Informatics for Healthcare, Research, and Applications
CityVirtual, Online
Period3/21/223/27/22

Keywords

  • Hepatic Decompensation
  • Machine learning
  • Persistent Homology
  • Topological data Analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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