A new prognostic tool for patients undergoing radiotherapy plus upfront transurethral resection for bladder cancer

Lisa Manig, Stefan Janssen, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To create a tool to estimate overall survival (OS) of patients with non-metastatic bladder cancer. Patients and Methods: Eight parameters were retrospectively evaluated for OS in 42 patients undergoing radiotherapy and upfront transurethral resection for bladder cancer. The prognostic tool included those parameters that were significant on both univariate and multivariate analyses. The tool was based on the 3-year OS rate divided by 10. Patient scores were calculated by adding the points for each significant parameter. Results: On univariate analysis, 3- year OS was associated with gender (p=0.017), pack years (p=0.009) and Karnofsky performance score (KPS) (p<0.001). On Cox regression, pack years (p=0.007) and KPS (p<0.001) remained significant and were incorporated into the tool. Three prognostic groups were designated with 6, 10-11 and 15 points with 3-year OS-rates of 0%, 34% and 83%, respectively (p<0.001). Conclusion: A tool was developed to estimate the OS of patients with bladder cancer to improve individualization of treatment.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalIn Vivo
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

Radiotherapy
Urinary Bladder Neoplasms
Survival
Survival Rate
Multivariate Analysis

Keywords

  • Bladder cancer
  • Overall survival
  • Prognostic tool
  • Radiotherapy
  • Transurethral resection

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

A new prognostic tool for patients undergoing radiotherapy plus upfront transurethral resection for bladder cancer. / Manig, Lisa; Janssen, Stefan; Schild, Steven E.; Rades, Dirk.

In: In Vivo, Vol. 31, No. 4, 01.07.2017, p. 745-748.

Research output: Contribution to journalArticle

Manig, Lisa ; Janssen, Stefan ; Schild, Steven E. ; Rades, Dirk. / A new prognostic tool for patients undergoing radiotherapy plus upfront transurethral resection for bladder cancer. In: In Vivo. 2017 ; Vol. 31, No. 4. pp. 745-748.
@article{5a5a2f5e478449f8bdaa174ae5954590,
title = "A new prognostic tool for patients undergoing radiotherapy plus upfront transurethral resection for bladder cancer",
abstract = "Aim: To create a tool to estimate overall survival (OS) of patients with non-metastatic bladder cancer. Patients and Methods: Eight parameters were retrospectively evaluated for OS in 42 patients undergoing radiotherapy and upfront transurethral resection for bladder cancer. The prognostic tool included those parameters that were significant on both univariate and multivariate analyses. The tool was based on the 3-year OS rate divided by 10. Patient scores were calculated by adding the points for each significant parameter. Results: On univariate analysis, 3- year OS was associated with gender (p=0.017), pack years (p=0.009) and Karnofsky performance score (KPS) (p<0.001). On Cox regression, pack years (p=0.007) and KPS (p<0.001) remained significant and were incorporated into the tool. Three prognostic groups were designated with 6, 10-11 and 15 points with 3-year OS-rates of 0{\%}, 34{\%} and 83{\%}, respectively (p<0.001). Conclusion: A tool was developed to estimate the OS of patients with bladder cancer to improve individualization of treatment.",
keywords = "Bladder cancer, Overall survival, Prognostic tool, Radiotherapy, Transurethral resection",
author = "Lisa Manig and Stefan Janssen and Schild, {Steven E.} and Dirk Rades",
year = "2017",
month = "7",
day = "1",
doi = "10.21873/invivo.11125",
language = "English (US)",
volume = "31",
pages = "745--748",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "4",

}

TY - JOUR

T1 - A new prognostic tool for patients undergoing radiotherapy plus upfront transurethral resection for bladder cancer

AU - Manig, Lisa

AU - Janssen, Stefan

AU - Schild, Steven E.

AU - Rades, Dirk

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Aim: To create a tool to estimate overall survival (OS) of patients with non-metastatic bladder cancer. Patients and Methods: Eight parameters were retrospectively evaluated for OS in 42 patients undergoing radiotherapy and upfront transurethral resection for bladder cancer. The prognostic tool included those parameters that were significant on both univariate and multivariate analyses. The tool was based on the 3-year OS rate divided by 10. Patient scores were calculated by adding the points for each significant parameter. Results: On univariate analysis, 3- year OS was associated with gender (p=0.017), pack years (p=0.009) and Karnofsky performance score (KPS) (p<0.001). On Cox regression, pack years (p=0.007) and KPS (p<0.001) remained significant and were incorporated into the tool. Three prognostic groups were designated with 6, 10-11 and 15 points with 3-year OS-rates of 0%, 34% and 83%, respectively (p<0.001). Conclusion: A tool was developed to estimate the OS of patients with bladder cancer to improve individualization of treatment.

AB - Aim: To create a tool to estimate overall survival (OS) of patients with non-metastatic bladder cancer. Patients and Methods: Eight parameters were retrospectively evaluated for OS in 42 patients undergoing radiotherapy and upfront transurethral resection for bladder cancer. The prognostic tool included those parameters that were significant on both univariate and multivariate analyses. The tool was based on the 3-year OS rate divided by 10. Patient scores were calculated by adding the points for each significant parameter. Results: On univariate analysis, 3- year OS was associated with gender (p=0.017), pack years (p=0.009) and Karnofsky performance score (KPS) (p<0.001). On Cox regression, pack years (p=0.007) and KPS (p<0.001) remained significant and were incorporated into the tool. Three prognostic groups were designated with 6, 10-11 and 15 points with 3-year OS-rates of 0%, 34% and 83%, respectively (p<0.001). Conclusion: A tool was developed to estimate the OS of patients with bladder cancer to improve individualization of treatment.

KW - Bladder cancer

KW - Overall survival

KW - Prognostic tool

KW - Radiotherapy

KW - Transurethral resection

UR - http://www.scopus.com/inward/record.url?scp=85028548503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028548503&partnerID=8YFLogxK

U2 - 10.21873/invivo.11125

DO - 10.21873/invivo.11125

M3 - Article

VL - 31

SP - 745

EP - 748

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 4

ER -