A new prognostic instrument specifically designed for patients irradiated for recurrent carcinoma of the bladder

Lisa Manig, Stefan Janssen, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background/Aim: To develop an instrument that could estimate the 1-year survival probabilities of patients irradiated for recurrent carcinoma of the bladder. Patients and Methods: Thirty patients irradiated for locally recurrent bladder carcinoma were included. Six pre-treatment factors [age, gender, Karnofsky score (KPS), pack years, grading and time between cancer diagnosis and radiotherapy] were evaluated for survival. Of those factors showing a trend or significance on multivariate analysis, 1-year survival rates were added. Results: On multivariate analysis, KPS was significant (hazard ratio(HR)=3.76, p=0.008), age showed a trend (HR=2.04, p=0.13). Patient scores were five, nine, ten or fourteen points with 1-year survival rates of 13%, 25%, 57% and 82% (p=0.003). Three groups were designed, A (5-9 points), B (10 points) and C (14 points) with 1-year survival rates of 17%, 57% and 82% (p=0.001). Conclusion: This score, including three groups with different 1-year survival probabilities, can aid physicians treating patients with recurrent bladder carcinoma.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalIn Vivo
Volume31
Issue number3
DOIs
StatePublished - May 1 2017

Keywords

  • Irradiation
  • Locally recurrent carcinoma of the bladder
  • Pre-treatment factors
  • Predictive score
  • Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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