A new paradigm in viral resistance

Autumn Ruiz; Stephen J. Russell

doi:10.1038/cr.2012.139

A new paradigm in viral resistance

Autumn Ruiz, Stephen J. Russell

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins. Therefore, a novel approach to the development of antivirals centers on targeting host factors critical to viral replication. A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors, suggesting that a combination of drugs with various targets may be necessary for preventing resistance.

Original language	English (US)
Pages (from-to)	1515-1517
Number of pages	3
Journal	Cell Research
Volume	22
Issue number	11
DOIs	https://doi.org/10.1038/cr.2012.139
State	Published - Nov 2012

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2012.139

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title = "A new paradigm in viral resistance",

abstract = "The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins. Therefore, a novel approach to the development of antivirals centers on targeting host factors critical to viral replication. A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors, suggesting that a combination of drugs with various targets may be necessary for preventing resistance.",

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A new paradigm in viral resistance

Abstract

ASJC Scopus subject areas

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