A new humanized HLA transgenic mouse model of multiple sclerosis expressing class II on mouse CD4 T cells

Ashutosh Mangalam, Moses Rodriguez, Chella David

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Among all the genetic factors associated with susceptibility to multiple sclerosis (MS), the strongest association has been seen with expression of certain major histocompatibility complex (MHC) class II molecules, although analysis of their exact function remains complicated. In general, the expression of class II is restricted to professional antigen-presenting cells; however, human but not mouse CD4+ T cells express class II on their surface. Functional studies of class II+ CD4+ T cells have been hampered due to lack of a proper animal model. Here, we describe development and characterization of a new humanized class II transgenic (tg) mouse expressing HLA-DR3 on mouse endogenous class II-negative background.

Original languageEnglish (US)
Title of host publicationHow Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis
PublisherBlackwell Publishing Inc.
Pages112-117
Number of pages6
ISBN (Print)1573316784, 9781573316781
DOIs
StatePublished - Apr 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1103
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antigen-presenting cells
  • CD4 T cells
  • EAE
  • MHC/HLA
  • MS
  • PLP
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Mangalam, A., Rodriguez, M., & David, C. (2007). A new humanized HLA transgenic mouse model of multiple sclerosis expressing class II on mouse CD4 T cells. In How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis (pp. 112-117). (Annals of the New York Academy of Sciences; Vol. 1103). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1394.005